目的 探討酪酸梭菌二聯(lián)活菌聯(lián)合諾氟沙星治療急性腸炎的臨床療效。方法 選取2015年12月—2018年12月內(nèi)蒙古師范大學(xué)醫(yī)院收治的急性腸炎患者80例作為研究對(duì)象，用隨機(jī)數(shù)字表法將患者分為對(duì)照組和觀察組，每組各40例。對(duì)照組給予諾氟沙星膠囊，首劑量0.4 g，從第2次服用開(kāi)始逐漸減少劑量，降至0.2 g/次，4次/d。觀察組在對(duì)照組治療的基礎(chǔ)上口服酪酸梭菌二聯(lián)活菌膠囊，3粒/次，2次/d。兩組均連續(xù)治療7 d。觀察兩組患者的臨床療效和臨床癥狀改善情況，同時(shí)比較兩組治療前后的免疫功能指標(biāo)水平。結(jié)果 治療后，觀察組臨床總有效率為92.50%，顯著高于對(duì)照組的72.50%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，觀察組患者嘔吐、腹痛和腹瀉消失時(shí)間均顯著短于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，觀察組的CD3⁺、CD4⁺和CD4⁺/CD8⁺水平顯著升高，CD8⁺水平降低（P<0.05）；且觀察組治療后免疫功能指標(biāo)顯著優(yōu)于對(duì)照組（P<0.05）。結(jié)論 酪酸梭菌二聯(lián)活菌聯(lián)合諾氟沙星可顯著縮短急性腸炎患者的癥狀消失時(shí)間、提高免疫功能及臨床治療效果，值得臨床借鑒。

Objective To investigate the clinical effect of Combined Clostridium Butyricum and Bifidobacterium Capsules, Live combined with norfloxacin in treatment of acute enteritis. Methods Patients (80 cases) with acute enteritis from December 2015 to December 2018 in The Hospital of Inner Mongolia Normal University were divided into control and observation group by the random number table method, and each group had 40 cases. Patients in the control group were given Norfloxacin Capsules at the first dose of 0.4 g, and gradually reduced the dose from the second dose to 0.2 g/time, four times daily. Patients in the observation group were po administered with Combined Clostridium Butyricum and Bifidobacterium Capsules, Live on the basis of control group, 3 grains/time, twice daily. Both groups were treated continuously for 7 d. The clinical efficacy and improvement of clinical symptoms of patients in two groups were observed, the levels of immune function indexes before and after treatment in two groups were compared. Results After treatment, the total clinical effective rate in the observation group was 92.50%, which was significantly higher than 72.50% in the control group, and the difference between two groups was statistically significant (P<0.05).After treatment, the disappearance time of vomiting, abdominal pain, and diarrhea in the observation group was significantly shorter than that in the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in two groups were significantly increased, but the levels of CD8⁺ were decreased (P<0.05).After treatment, the immune function indexes in the observation group were significantly better than those in the control group (P<0.05). Conclusion Combined Clostridium Butyricum and Bifidobacterium Capsules, Live combined with norfloxacin can significantly shorten the symptom disappearance time of patients with acute enteritis, improve the immune function and clinical therapeutic effect, which is worthy of clinical reference.

R975