中藥復方作為中醫(yī)臨床用藥最廣泛的形式，其藥效物質(zhì)基礎和作用機制的科學闡釋成為全面揭示中醫(yī)藥實用價值進而實現(xiàn)中藥現(xiàn)代化的關鍵。代謝組學技術始于20世紀90年代中期，旨在利用現(xiàn)代科學技術研究生物體系在受到刺激或干擾后，內(nèi)源性代謝物組的變化或隨時間的變化規(guī)律，以代謝物組分析為基礎，借助高通量檢測和多元化數(shù)據(jù)處理手段，整合多維生物信息系統(tǒng)，闡明中藥復方的藥效物質(zhì)基礎和作用機制。綜述了最新代謝組學技術的研究進展及在中藥復方藥效物質(zhì)基礎和作用機制研究中的應用情況，并對代謝組學技術未來發(fā)展趨勢進行展望。

Traditional Chinese medicine(TCM) prescriptions is the most extensive form in clinical parctice for traditional Chinese medicine, and its effective substances and mechanism is key to achieve modernization and comprehensively reveal the essence of traditional Chinese medicine theory. Metabolomics began in the mid-1990s with the aim of using modern science and technology to probe into the endogenous metabolites changes and time-dependent discipline after stimulation or interference in biological systems. It clarifies effective substances and mechanism based on metabolite analysis, high-throughput detection, diversity data processing andsystematic information integration. In this paper, we reviewed metabolomics technology development in recent years and its application in effective substances and mechanism of TCM prescriptions research. Meanwhile, modernization research and the future trend were also discussed.

國家重大科技專項重大新藥創(chuàng)制——中醫(yī)藥優(yōu)勢領域的創(chuàng)新中藥關鍵技術開發(fā)研究（2017ZX09301005