目的 觀察注射用益氣復(fù)脈（凍干）治療慢性心力衰竭伴低血壓的療效。方法 選取鄭州市中醫(yī)院2018年10月-2020年2月心內(nèi)一科收治的120例慢性心力衰竭并低血壓患者，采用隨機(jī)數(shù)字法分為對(duì)照組（53例）和觀察組（55例）。對(duì)照組針對(duì)原發(fā)病進(jìn)行一般治療。觀察組在對(duì)照組治療的基礎(chǔ)上給予注射用益氣復(fù)脈（凍干），2.6~5.2 g加入5%葡萄糖注射液或0.9%氯化鈉注射液250~500 mL中靜滴，1次/d，連續(xù)使用7~14 d。觀察兩組患者的臨床療效，同時(shí)比較兩組患者治療前后的左室射血分?jǐn)?shù)（LVEF）、N端腦鈉肽前體（NT-proBNP）、心率、生活質(zhì)量評(píng)分和血壓水平。結(jié)果 治療后，觀察組患者總有效率為96.4%，顯著高于對(duì)照組的84.9%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組LVEF顯著升高，NT-proBNP、心率和生活質(zhì)量評(píng)分均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；觀察組在NTproBNP水平和生活質(zhì)量評(píng)分顯著低于于對(duì)照組（P<0.05）。治療后，兩組血壓均有明顯升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05），治療后，觀察組的血壓水平顯著高于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 注射用益氣復(fù)脈（凍干）治療慢性心力衰竭合并低血壓不僅能有效改善患者的心功能，減輕臨床癥狀，而且能進(jìn)一步提升低血壓患者的血壓水平。

Objective To observe the curative effect of Yiqi Fumai Lyophilized Injection in treatment of chronic heart failure with hypotension. Methods 120 cases of patients with chronic heart failure and hypotension in the Zhengzhou Municipal Hospital of TCM from October 2018 to February 2020 were randomly divided into control group (53 cases) and observation group (55 cases). Patients in the control group received general treatment for the primary disease. Patients in the observation group were injected with Yiqi Fumai Lyophilized Injection on the basis of control group, 2.6 g-5.2 g added with 5% glucose injection or 0.9% sodium chloride injection for 250-500 mL, once daily, and patients were continuously treated for 7-14 d. After treatment, the clinical efficacy in two groups were observed, and the LVEF, NT-proBNP, heart rate, quality of life score, and blood pressure level in two groups before and after treatment were compared. Results After treatment, the total effective rate in the observation group was 96.4%, which was significantly higher than 84.9% in the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, LVEF in two groups was significantly increased, but NT-proBNP, heart rate, and quality of life scores were significantly reduced, and the differences before and after treatment in the same group were statistically significant (P<0.05). And the NT-proBNP level and quality of life score in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the blood pressure in two groups were increased significantly, and the difference in the same group before and after treatment was statistically significant (P<0.05). After treatment, the blood pressure level in the observation group was significantly higher than that in the control group, and the difference between two groups was statistically significant (P<0.05). Conclusion Yiqi Fumai Lyophilized Injection in treatment of chronic heart failure with hypotension can not only effectively improve the cardiac function of patients, reduce clinical symptoms, but also further improve the blood pressure level of patients with hypotension.

R972