目的 注射用益氣復(fù)脈（凍干）聯(lián)合左西孟旦對(duì)慢性心力衰竭患者心功能、血流動(dòng)力學(xué)和炎性因子的影響。方法 選取2018年10月-2019年10月聊城市中醫(yī)醫(yī)院收治的慢性心力衰竭住院患者100例為研究對(duì)象，將患者按入組順序進(jìn)行編號(hào)分為對(duì)照組和觀察組，每組各50例。對(duì)照組給予左西孟旦注射液治療，設(shè)定初始負(fù)荷劑量為12 μg/kg，持續(xù)注射10 min；之后以0.1 μg/（kg·min）劑量靜脈滴注，1 h后將滴注劑量增至0.2 μg/（kg·min）并持續(xù)滴注23 h。觀察組在對(duì)照組治療基礎(chǔ)上靜脈滴注注射用益氣復(fù)脈（凍干），1.3 g藥液溶至5%葡萄糖注射液250 mL中，1次/d，連續(xù)治療14 d。比較兩組患者治療前后的心功能指標(biāo)、血流動(dòng)力學(xué)和炎性因子水平。結(jié)果 治療后，兩組腦鈉肽（BNP）水平均顯著降低，每搏心輸出量（SV）、左室射血分?jǐn)?shù)（LVEF）及6 min步行試驗(yàn)距離均顯著升高（P<0.05）；且觀察組患者BNP顯著低于對(duì)照組，SV、LVEF及6 min步行試驗(yàn)距離顯高于對(duì)照組（P<0.05）。治療后，兩組心率（HR）、收縮壓（SBP）及舒張壓（DBP）均顯著降低（P<0.05）；觀察組患者HR顯著低于對(duì)照組，SBP、DBP顯著高于對(duì)照組（P<0.05）。治療后，兩組血漿超敏C反應(yīng)蛋白（hs-CRP）、腫瘤壞死因子-α（TNF-α）及白介素-6（IL-6）水平均顯著降低（P<0.05）；觀察組患者血漿hsCRP、TNF-α及IL-6水平顯著低于對(duì)照組（P<0.05）。結(jié)論 采用注射用益氣復(fù)脈（凍干）聯(lián)合左西孟旦治療慢性心力衰竭，可顯著改善心功能和血流動(dòng)力學(xué)指標(biāo)，抑制全身炎癥反應(yīng)，其效果優(yōu)于單純左西孟旦治療。

Objective Effects of injection of Yiqi Fumai Lyophilized Injection combined with levosimendan on cardiac function, hemodynamics and inflammatory factors in patients with chronic heart failure. Methods A total of 100 patients with chronic heart failure admitted to Liaocheng Traditional Chinese Medicine Hospital from October 2018 to October 2019 were selected as the research objects, and the patients were numbered according to the inclusion sequence and divided into the control group and the observation group, with 50 patients in each group. Patients in the control group was given Levosimendan Injection, the initial loading dose was set as 12 μg/kg lasted for 10 min. After intravenous infusion at 0.1 μg/(kg·min) for 1 h, the infusion dose was increased to 0.2 μg/(kg·min) and continued for 23 h. Patients in the observation group were iv administered with Yiqi Fumai Lyophilized Injection on the basisi of control group, 1.3 g was dissolved into 5% glucose injection 250 mL, once daily, and the treatment lasted for 14 d. After treatment, the levels of cardiac function, hemodynamics and inflammatory factors before and after treatment were compared between two groups. Results After treatment, the levels of BNP were significantly decreased in two groups, but the SV, LVEF, and the 6 min walking distance were significantly increased (P<0.05). And BNP in the observation group was significantly lower than that in the control group, SV, LVEF and the 6 min walking distance were significantly higher than those in the control group (P<0.05). After treatment, HR, SBP, and DBP were significantly decreased in two groups (P<0.05). HR in the observation group was significantly lower than that in the control group, SBP and DBP were significantly higher than those in the control group (P<0.05). After treatment, plasma hs-CRP, TNF-α, and IL-6 levels in two groups were significantly decreased (P<0.05). The plasma hs-CRP, TNF-α, and IL-6 levels in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Yiqi Fumai Lyophilized Injection combined with levosimendan in treatment of patients with chronic heart failure can significantly improve the cardiac function and hemodynamic indicators, and inhibit systemic inflammatory response. The effect is better than that of levosimendan alone.

R972