目的 觀察注射用丹參多酚酸聯(lián)合阿司匹林治療急性大動脈粥樣硬化型腦梗死臨床療效。方法 選取2017年2月-2018年1月在保定市第一中心醫(yī)院就診的急性大動脈粥樣硬化型腦梗死患者202例作為研究對象，采用隨機數(shù)字表法將患者分為對照組和觀察組，每組各101例。對照組晨起空腹口服阿司匹林腸溶片，100 mg/次，1次/d。觀察組在對照組治療的基礎上靜脈輸注注射用丹參多酚酸，0.13 g加入到生理鹽水250 mL中稀釋，1次/d。兩組均治療14 d。觀察兩組患者的臨床療效，同時比較兩組治療前后的美國國立衛(wèi)生研究院卒中量表（NIHSS）評分、半乳糖凝集素-3（GLA-3）和白細胞介素-6（IL-6）水平。結果 治療后，對照組和觀察組的總有效率分別為63.4%和75.2%，兩組總有效率比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組組NIHSS評分均顯著下降（P<0.05），且觀察組NIHSS評分顯著低于對照組（P<0.05）。治療后，兩組的血清IL-6和GLA-3水平均顯著下降（P<0.05），且觀察組IL-6和GLA-3水平顯著低于對照組（P<0.05）。結論 注射用丹參多酚酸聯(lián)合阿司匹林治療急性大動脈粥樣硬化型腦梗死可促進患者神經(jīng)功能恢復，改善患者的生活質量，降低炎性因子水平，且安全性較高，具有一定的臨床應用價值。

Objective To observe the clinical effect of Salvianolic Acids for Injection combined with aspirin in treatment of acute atherosclerotic cerebral infarction. Methods A total of 202 patients with acute atherosclerotic cerebral infarction in the Baoding NO.1 Center Hospital from February 2017 to January 2018 were selected as the study subjects. Patients were divided into control group and observation group by random number table method, with 101 patients in each group. Patients in the control group were po administered with Aspirin Enteric-coated Tablets with empty stomach in the morning, 100 mg/time, once daily. Patients in the observation group were iv administered with Salvianolic Acids for Injection on the basis of control group, 0.13 g was added to 250 mL normal saline for dilution, once daily. Both groups were treated for 14 d. The clinical efficacy in two groups was observed, and the NIHSS score, GLA-3 and IL-6 levels of two groups before and after treatment were compared. Results After treatment, the total effective rate in the control group and the observation group was 63.4% and 75.2%, respectively, with statistically significant difference between the two groups (P<0.05). After treatment, NIHSS score in two groups were decreased significantly (P<0.05), and the NIHSS score in the observation group was significantly lower than that in the control group (P<0.05). After treatment, serum IL-6 and GLA-3 levels in two groups were significantly decreased (P<0.05), and IL-6 and GLA-3 levels in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Salvianolic Acids for Injection combined with aspirin in treatment of acute atherosclerotic cerebral infarction can promote the recovery of nerve function, improve the quality of life of the patients, reduce the level of inflammatory factors, and is relatively safe, which has a certain clinical application value.

R971

河北省醫(yī)學科學研究重點課題（20181487）