目的 探討注射用丹參多酚酸聯(lián)合氨氯地平、阿托伐他汀對高血壓患者內(nèi)皮功能的影響及安全性。方法 選取2018年3月-2019年3月蘭考中心醫(yī)院收治的高血壓患者126例，按入院先后順序分為對照組和觀察組（各63例）。對照組在常規(guī)治療的基礎上口服氨氯地平5 mg+阿托伐他汀10 mg聯(lián)合治療，觀察組在對照組治療的基礎上+注射用丹參多酚酸0.13 g靜脈滴注，所有患者均治療14 d。于治療前后對兩組患者的收縮壓（SBP）、舒張壓（DBP）、C-反應蛋白（CRP）、一氧化氮（NO）、內(nèi)皮素-1（ET-1）水平和不良反應進行比較。結果 治療后，兩組患者SBP、DBP水平均明顯下降，與同組治療前比較差異均有顯著性（P<0.05），且觀察組SBP下降水平明顯優(yōu)于對照組（P<0.05）；兩組CRP、ET-1水平均較治療前明顯下降、NO水平明顯升高（P<0.05），且觀察組優(yōu)于對照組（P<0.05）。治療過程中，對照組患者不良反應發(fā)生率為14.29%，觀察組為12.70%，兩組比較無差異。結論 對高血壓患者在氨氯地平、阿托伐他汀鈣片聯(lián)合治療的基礎上應用注射用丹參多酚酸，可以明顯提高治療效果，改善患者內(nèi)皮功能，值得進一步臨床研究與應用。

Objective To investigate the effect and safety of Salvianolic Acid for Injection combined with amlodipine and atorvastatin on endothelial function in patients with hypertension. Methods A total of 126 patients with hypertension in Lankao Central Hospital from March 2018 to March 2019 were selected, according to the order of admission, they were divided into control group and observation group (63 cases in each group). The control group was given amlodipine 5 mg and atorvastatin 10 mg oral on the conventional treatment, while the observation group was given Salvianolic Acid for Injection of 0.13 g on the basis of control group, all patients were treated for 14 days. Systolic blood pressure (SBP), diastolic blood pressure (DBP), C-reactive protein (CRP), nitric oxide (NO) and endothelin-1 (ET-1) and adverse reactions were detected and compared between the two groups before and after treatment. Results After treatment, the levels of SBP and DBP in the observation group were significantly decreased, compared with the same group before treatment, the difference was significant (P<0.05), and DBP level of the observation group was significantly better than that of the control groupt(P<0.05); the levels of CRP and ET-1 in the two groups were significantly decreased, and the level of NO was significantly increased, compared with that before treatment in the same group, the differences were significant (P<0.05), and the difference between two groups was also significant (P<0.05). During the treatment, the incidence of adverse reactions in the control group was 14.29%, and the observation group was 12.70%, there was no significant difference in the incidence of adverse reactions between two groups. Conclusion On the basis of amlodipine and atorvastatin added Salvianolic Acid for Injection, it can significantly improve the treatment effect and improve the endothelial function of patients, which is worthy of further clinical research and application.

R285.6;R286.2