0)、胸骨完全閉合后(T1)、術(shù)后第1天(T3)、術(shù)后第3天(T3)記錄患者氧合指數(shù)(PaO2/FiO2)、肺泡動(dòng)脈血氧分壓差(A-aDO2)。并于T0、T1記錄肺動(dòng)態(tài)順應(yīng)性(Cd)、肺靜態(tài)順應(yīng)性(Cs)。觀察患者術(shù)后其他并發(fā)癥發(fā)生情況。結(jié)果 與T0時(shí)刻比較,兩組T1~T3時(shí)刻PaO2/FiO2、A-aDO2明顯降低(P<0.01);兩組T1時(shí)刻Cd、Cs明顯升高(P<0.05)。維生素C組術(shù)后肺部并發(fā)癥發(fā)生率為12.12%,顯著低于對照組的29.73%(P<0.05)。與對照組相比,維生素C組患者術(shù)后肺部評分顯著降低(P<0.01)。術(shù)后患者其他并發(fā)癥以房顫最常見,但兩組間差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 術(shù)中iv維生素C能夠降低心臟手術(shù)患者術(shù)后肺部并發(fā)癥評分,減少術(shù)后肺部并發(fā)癥發(fā)生率,改善患者的肺功能。;Objective To observe the effect of intravenous injection of Vitamin C on postoperative pulmonary complications in patients undergoing cardiac surgery. Methods A total of 70 patients who underwent cardiopulmonary bypass in the Affiliated Hospital of Xuzhou Medical University from December 2018 to August 2019 were selected as study subjects, and the patients were divided into control group (37 cases) and vitamin C group (33 cases) by random sequence method. Patients in the vitamin C group were iv administered with Vitamin C injection at 10 min after anesthesia induction, 10 min before cardiopulmonary bypass, and complete closure of sternum, respectively, 1 g was diluted with normal saline 10 mL, and the total amount was 3 g. Patients in the control group received 10 mL of normal saline intravenously at the same time. The incidence, severity score and types of postoperative pulmonary complications were recorded. Patients' PaO2/FiO2 and A-aDO2 were recorded at 10 min after intubation (T0), after complete sternal closure (T1), first day after surgery (T3), and third day after surgery (T3). And the Cd and Cs were recorded at T0 and T1. Other postoperative complications were observed. Results Compared with time of T0, PaO2/FiO2 and A-aDO2 in two groups were significantly reduced at time of T1-T3 (P<0.01), and the Cd and Cs were significantly increased in two groups at time of T1 (P<0.05). The incidence of postoperative pulmonary complications in the vitamin C group was 12.12%, which was significantly lower than 29.73% in the control group (P<0.05). Compared with the control group, postoperative pulmonary scores in the vitamin C group were significantly decreased (P<0.01). Atrial fibrillation was the most common postoperative complication, but there was no significant difference between two groups. Conclusion Intraoperative intravenous vitamin C can reduce postoperative pulmonary complications score, reduce the incidence of postoperative pulmonary complications, and improve the pulmonary function of patients undergoing cardiac surgery."/> 2/FiO2;A-aDO2;Cd;Cs"/>

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首頁 > 過刊瀏覽>2020年第43卷第9期 >2020,43(9):1809-1814. DOI:10.7501/j.issn.1674-6376.2020.09.023
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術(shù)中iv維生素C對心臟手術(shù)患者術(shù)后肺部并發(fā)癥的影響

Effect of intravenous injection of Vitamin C on postoperative pulmonary complications in patients undergoing cardiac surgery

發(fā)布日期:2020-09-02
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