目的 探討奧美沙坦酯與氨氯地平聯(lián)合氫氯噻嗪治療高血壓的療效對比。方法 選取2017年2月—2019年2月新疆喀什地區(qū)第二人民醫(yī)院治療的100例高血壓患者為研究對象，根據(jù)隨機(jī)數(shù)字表法將患者分為對照組和觀察組，每組各50例。對照組患者口服苯磺酸氨氯地平片，5 mg/次，1次/d；氫氯噻嗪片，25 mg/次，1次/d。觀察組患者口服奧美沙坦酯片，20 mg/次，1次/d。氫氯噻嗪片用法同對照組。兩組均連續(xù)治療2個月。觀察兩組患者的臨床療效，同時比較兩組患者治療前后的24 h動態(tài)血壓情況和血清因子水平。結(jié)果 治療后，觀察組患者的降壓總有效率為92.00%，顯著高于對照組的74.00%（P<0.05）。治療后，兩組患者24 h動態(tài)血壓均明顯降低（P<0.05），且觀察組顯著低于對照組（P<0.05）。治療后，兩組患者同型半胱氨酸（Hcy）、超敏C反應(yīng)蛋白（hs-CRP）水平均明顯降低（P<0.05），且觀察組各血清因子水平均顯著低于對照組（P<0.05）。結(jié)論 奧美沙坦酯聯(lián)合氫氯噻嗪可有效控制血壓水平，降低血清因子水平，對促進(jìn)高血壓患者病情康復(fù)具有積極意義。

Objective To compare the efficacy of olmesartan medoxomil and amlodipine combined with hydrochlorothiazide in treatment of hypertension. Methods A total of 100 patients with hypertension in the Kashgar Second People's Hospital, Xinjiang from February 2017 to February 2019 were selected as the research objects. According to the random number table method, the patients were divided into the control group and the observation group, with 50 patients in each group. Patients in the control group were po administered with Amlodipine Besylate Tablets, 5 mg/time, once daily, and Hydrochlorothiazide Tablets, 25 mg/time, once daily. Patients in the observation group were po administered with Olmesartan Medoxomil Tablets, 20 mg/time, once daily, and Hydrochlorothiazide Tablets were used as the control group. Both groups were treated continuously for 2 months. The clinical efficacy of two groups was observed, and the 24 h dynamic blood pressure and serum factor levels before and after treatment in two groups were compared. Results After treatment, the total effective rate of hypotension in the observation group was 92.00%, which was significantly higher than 74.00% in the control group (P<0.05). After treatment, the 24 h dynamic blood pressure in two groups was significantly decreased (P<0.05), and 24 h dynamic blood pressure in the observation group was significantly lower than those in the control group (P<0.05). After treatment, the levels of Hcy and hs-CRP in two groups were significantly decreased (P<0.05), and the levels of serum factors in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Olmesartan medoxomil combined with hydrochlorothiazide can effectively control the blood pressure level and reduce the serum factor level, which is of positive significance for promoting the rehabilitation of hypertension patients.

R972

新疆維吾爾族自治區(qū)科技支疆項(xiàng)目計(jì)劃（指令性）項(xiàng)目（2018E02114）