目的 研究三七丹參膠囊聯(lián)合葉黃素和阿托伐他汀治療頸部血管斑塊的效果及安全性。方法 選取2017年1月—2018年1月安康市中醫(yī)醫(yī)院的98例頸部血管斑塊患者作為研究對(duì)象。用抽簽法隨機(jī)分為對(duì)照組和觀察組，每組各49例。對(duì)照組患者口服阿托伐他汀鈣片，20 mg/次，1次/d；且口服葉黃素軟膠囊，2粒/次，2次/d。觀察組在對(duì)照組的基礎(chǔ)上口服三七丹參膠囊，3粒/次，3次/d。兩組患者均治療3個(gè)月。觀察兩組患者的臨床療效，同時(shí)比較兩組患者的中醫(yī)癥候評(píng)分、Crouse斑塊積分、血管內(nèi)中膜厚度（IMT）和不良心血管事件情況。結(jié)果 治療后，觀察組的總有效率為81.63%，顯著高于對(duì)照組為59.18%（P<0.05）。兩組治療后的心悸不安、頭痛、胸悶不舒、舌質(zhì)紫暗、唇甲紫紺、結(jié)代或脈澀積分明顯降低（P<0.05），觀察組上述中醫(yī)證候評(píng)分明顯低于對(duì)照組（P<0.05）。兩組治療后的Crouse斑塊積分和IMT明顯降低（P<0.05），觀察組Crouse斑塊積分和IMT明顯低于對(duì)照組（P<0.05）。治療期間，觀察組的急性心肌梗死、不穩(wěn)定型心絞痛、腦出血和急性腦梗死發(fā)生率顯著低于對(duì)照組（P<0.05）。結(jié)論 三七丹參膠囊聯(lián)合葉黃素軟膠囊能明顯減輕頸部血管斑塊患者的癥狀，促進(jìn)斑塊面積的縮小，安全性高，且能降低不良心血管事件的發(fā)生風(fēng)險(xiǎn)。

Objective To study the efficacy and safety of Sanqi Danshen Capsules combined with lutein and atorvastatin in treatment of cervical vascular plaques. Methods A tatal of 98 patients with cervical vascular plaques in Ankang Hospital of Traditional Chinese Medicine from January 2017 to January 2018 were selected as the research objects. And the patients were randomly divided into control group and observation group with 49 cases in each group. Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. And Lutein Soft Capsules 2 grains/time for twice daily. Patients in the observation group were po administered with Sanqi Danshen Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in both groups were treated for 3 months. After treatment, the clinical efficacy in two groups were observed, and the traditional Chinese medicine syndrome score, Crouse plaque score, IMT and adverse cardiovascular events of two groups were compared. Results After treatment, the total effective rate in the observation group was 81.63%, which was significantly higher than 59.18% of the control group (P<0.05). After treatment, palpitation and discomfort, headache, chest discomfort, purplish color of tongue, cyanosis of labial nail, knot or pulse-astringency scores were significantly reduced in two groups (P<0.05), and the TCM syndrome score in the observation group was significantly lower than that in the control group (P<0.05). After treatment, the Crouse plaque scores and IMT in two groups were significantly reduced (P<0.05), and the Crouse plaque scores and IMT in the observation group were significantly lower than those of the control group (P<0.05). During treatment, the incidence of acute myocardial infarction, unstable angina pectoris, cerebral hemorrhage, and acute cerebral infarction in the observation group was significantly lower than that in the control group (P<0.05). Conclusion Sanqi Danshen Capsules combined with Lutein Soft Capsules can significantly reduce the symptoms of cervical vascular plaque patients, promote the reduction of plaque area, with high safety, and reduce the risk of adverse cardiovascular events.

R972

安康市科學(xué)技術(shù)研究發(fā)展項(xiàng)目（AK2019-SF-099）