目的 探索紅花注射液聯(lián)合塞來昔布治療腰椎間盤突出癥的臨床療效。方法 選取2017年9月—2019年7月焦作市人民醫(yī)院收治的50例腰椎間盤突出癥患者作為研究對象，隨機數(shù)字表法將患者分為對照組（n=25）和觀察組（n=25）。兩組均給予經(jīng)皮穿刺低溫等離子消融術(shù)治療，對照組口服塞來昔布膠囊，200 mg/次，1次/d。觀察組在對照組治療的基礎(chǔ)上在病變椎間盤下一個椎體棘突旁側(cè)注射紅花注射液，10 mL，1次/d。兩組共給藥14 d。觀察兩組患者的臨床療效，同時比較兩組患者的Oswestry功能障礙指數(shù)（ODI）、視覺模擬評分法（VAS）評分、血漿P物質(zhì)、血漿β-內(nèi)啡肽（β-EP）、白細胞介素-6（IL-6）、一氧化氮（NO）和Pfirrmann分級情況。結(jié)果 治療后，對照組和觀察組為總有效率比較差異無統(tǒng)計學(xué)意義。治療后，兩組患者的ODI評分和VAS評分均顯著降低（P<0.05）；且觀察組ODI評分和VAS評分均顯著低于對照組（P<0.05）。治療后，兩組P物質(zhì)和β-EP水平顯著升高，而IL-6和NO水平顯著降低（P<0.05）；且觀察組P物質(zhì)和β-EP水平顯著高于對照組，而觀察組IL-6和NO水平顯著低于對照組（P<0.05）。兩組Pfirrmann III級患者均高于IV級（P<0.05）。結(jié)論 紅花注射液聯(lián)合塞來昔布治療腰椎間盤突出癥可提高患者腰椎功能，改善炎癥狀態(tài)，有效緩解患者疼痛，調(diào)控炎癥因子及鎮(zhèn)痛物質(zhì)表達。

Objective To explore the clinical effect of Honghua Injection combined with Celecoxib in treatment of lumbar disc herniation. Methods A total of 50 patients with lumbar disc herniation admitted to Jiaozuo People's Hospital from September 2017 to July 2019 were selected as the research objects, and the patients were divided into control group (n=25) and observation group (n=25) by random number table method. Both groups were treated with percutaneous low-temperature plasma ablation, while patients in the control group were po administered with Celecoxib Capsules, 200 mg/time, once daily. Patients in the observation group were injected with Honghua Injection on the basis of control group at the side of the vertebral spine process under the diseased intervertebral disc, 10 mL, once daily. Patients in two groups were treated for 14 days. After treatment, the clinical efficacy in two groups was observed. And the ODI score, VAS score, plasma substance P, β -EP, IL-6, NO, and Pfirrmann grade were compared between two groups. Results After treatment, there was no statistically significant difference in the total effective rate between control group and observation group. After treatment, tHE ODI score and VAS score in two groups were significantly decreased (P<0.05). Moreover, ODI score and VAS score in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of substance P and β-EP were significantly increased in two groups, while the levels of IL-6 and NO were significantly decreased (P<0.05). Moreover, the levels of substance P and β -EP in the observation group were significantly higher than those in the control group, while the levels of IL-6 and NO in the observation group were significantly lower than those in the control group (P<0.05). Pfirrmann III patients in two groups were higher than grade IV patients (P<0.05). Conclusion Honghua Injection combined with celecoxib in treatment of lumbar disc herniation can improve the function of the lumbar spine, and the inflammatory state, effectively relieve the pain of patients, regulate the expression of inflammatory factors and analgesic substances.

R982

河南省科學(xué)技術(shù)計劃項目（2017225061）