目的 探討銀杏內(nèi)酯注射液對缺血性血管性認知障礙患者認知功能及血清血清超氧化物歧化酶（SOD）、谷胱甘肽（GSH）的影響。方法 選擇2018年1月—2019年1月沈陽醫(yī)學(xué)院附屬中心醫(yī)院治療的缺血性血管性認知障礙患者40例作為研究對象，采用隨機數(shù)字法將患者隨機分為對照組和觀察組，每組各20例。對照組患者進行常規(guī)治療。觀察組在常規(guī)治療基礎(chǔ)上靜脈滴注銀杏內(nèi)酯注射液，10 mL加入0.9%生理鹽水250 mL稀釋，1次/d。兩組患者均連續(xù)治療14 d。觀察兩組患者治療前后的簡易智力狀態(tài)檢查量表（MMSE）評分、日常生活活動能力量表（ADL）和血清抗氧化指標水平。結(jié)果 治療后，兩組患者認知能力明顯改善，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P<0.05）；治療后，觀察組患者認知能力的改善顯著優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者生活能力明顯改善，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P<0.05）；觀察組患者生活能力的改善顯著優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，觀察組血清SOD、GSH水平顯著升高，同組比較差異具有意義（P<0.05）；治療后，與對照組比較，觀察組患者血清SOD、GSH水平均顯著升高，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 缺血性血管性認知障礙患者在常規(guī)治療的基礎(chǔ)上加用銀杏內(nèi)酯注射液體不僅可以在短期內(nèi)改善智能狀態(tài)，而且可以顯著提高日常生活能力，其機制可能是與銀杏內(nèi)酯的抗氧化應(yīng)激作用帶來的神經(jīng)損傷修復(fù)作用有關(guān)。

Objective To investigate the effects of Ginkgolide Injection on cognitive function and serum SOD and GSH in patients with ischemic vascular cognitive impairment. Methods Patients (40 ceses) with ischemic vascular cognitive impairment in the Central Hospital Affiliated to Shenyang Medical College from January 2018 to January 2019 were devided into control and observation group by random number method, and each group had 20 ceses. Patients in the control group were received routine treatment. Patients in the observation group were iv administered with Ginkgolide Injection on the basis of control group, 10 mL was diluted with 0.9% normal saline 250 mL, once daily. Both groups were treated continuously for 14 d. The cognitive function, living ability, and serum antioxidant levels in two groups were observed before and after treatment. Results After treatment, the cognitive ability of patients in two groups was significantly improved, and the difference before and after treatment in the same group was statistically significant (P<0.05). After treatment, the improvement of cognitive ability in the observation group was significantly better than that in the control group, and the difference between the two groups was statistically significant (P<0.05). After treatment, the living ability in two groups was significantly improved, and the difference before and after treatment in the same group was statistically significant (P<0.05). And the improvement of living ability in the observation group was significantly better than that in the control group, and the difference between the two groups was statistically significant (P<0.05). After treatment, the serum levels of SOD and GSH in the observation group were significantly increased, the differences before and after treatment in the same group were statistically significant (P<0.05). After treatment, compared with the control group, the serum SOD and GSH levels in the observation group were significantly increased, and the differences between two groups were statistically significant (P<0.05). Conclusion Patients with ischemic vascular cognitive impairment adding Ginkgolide Injection on the basis of conventional treatment can not only improve the state of intelligence in a short time, but also significantly improve the ability of daily living, the mechanism may be related to the effect of antioxidant stress of ginkgolide on nerve damage repair.

R971

沈陽醫(yī)學(xué)院青年科學(xué)研究基金（20192041）