目的 研究氟哌噻噸美利曲辛聯(lián)合復(fù)方消化酶治療功能性消化不良的臨床療效。方法 選擇2016年1月—2018年1月開封市中心醫(yī)院的102例功能性消化不良患者作為研究對象，采用抽簽法將患者隨機分為對照組和觀察組，每組各51例。對照組患者在飯后30 min口服復(fù)方消化酶膠囊，2粒/次，3次/d。觀察組患者在對照組的基礎(chǔ)上分別于早晨和中午口服氟哌噻噸美利曲辛片，1片/次，2次/d。兩組患者均治療4周。觀察兩組患者的臨床療效，同時比較兩組治療前后的漢密爾頓焦慮量表（HAMA）、漢密爾頓抑郁量表（HAMD）和中醫(yī)癥候評分。結(jié)果 治療后，觀察組的總有效率為94.12%，明顯高于對照組的78.43%（P<0.05）。治療后，觀察組的HAMA和HAMD評分均明顯降低（P<0.05），且觀察組HAMA和HAMD評分明顯低于對照組（P<0.05）。治療后，對照組癥狀評分均明顯降低（P<0.05），觀察組各癥狀評分有所降低，但明顯高于對照組（P<0.05）。結(jié)論 氟哌噻噸美利曲辛聯(lián)合復(fù)方消化酶能顯著提高功能性消化不良的療效，減輕抑郁、焦慮狀況，緩解軀體癥狀，具有一定的臨床推廣應(yīng)用價值。

Objective To study the clinical effect of fupentixol and melitracen combined with compound digestive enzyme in treatment of functional dyspepsia. Methods A total of 102 patients with functional dyspepsia in Kaifeng Central Hospital from January 2016 to January 2018 were selected as the study subjects. The patients were randomly divided into control group and observation group by lottery, with 51 patients in each group. Patients in the control group were po administered with Compound Digestive Enzyme Capsules at 30 min after meals, 2 grains/time, three times daily. Patients in observation group were po administered with Flupentixol and Melitracen Tablets on the basis of the control group in the morning and noon, 1 tablet/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy in two groups were observed, HAMA and HAMD scores, and TCM syndrome scores before and after treatment were compared. Results After treatment, the total effective rate in the observation group was 94.12%, which was significantly higher than 78.43% in the control group (P<0.05). After treatment, HAMA and HAMD scores in the observation group were significantly decreased (P<0.05), and HAMA and HAMD scores in the observation group were significantly lower than those in the control group (P<0.05). After treatment, scores of symptoms in the control group were significantly decreased (P<0.05), scores of TCM symptoms in the observation group were decreased, but it was significantly higher than those in the control group (P<0.05). Conclusion Fupentixol and melitracen combined with compound digestive enzyme could significantly improve the efficacy of functional dyspepsia, alleviate depression and anxiety, and alleviate somatogenic symptoms, so it has certain clinical application value.

R975