目的 研究杏丁注射液聯(lián)合前列地爾對慢性腎衰竭患者的臨床療效。方法 選擇2015年3月—2018年3月榆林市第二醫(yī)院收治的100例慢性腎衰竭患者作為研究對象，將患者隨機(jī)分為對照組和觀察組，每組各50例。對照組靜脈滴注前列地爾注射液，10 μg加入到100 mL生理鹽水中，1次/d。觀察組在對照組治療的基礎(chǔ)上靜脈滴注杏丁注射液，20 mL加入生理鹽水250 mL，1次/d。兩組均治療2周。觀察兩組患者的臨床療效，同時比較兩組患者治療前后的腎功能指標(biāo)和氧化應(yīng)激功能指標(biāo)的水平。結(jié)果 治療后，對照組有效率為70.00%，觀察組有效率為86.00%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。兩組治療后的尿素氮（BUN）、24 h尿蛋白定量以及血肌酐（Scr）水平均明顯降低（P<0.05），且觀察組明顯低于對照組（P<0.05）。兩組治療后的超氧化物歧化酶（SOD）、晚期糖基化終末產(chǎn)物（AGEs）、丙二醛（MDA）、晚期蛋白質(zhì)氧化產(chǎn)物（AOPP）水平均明顯改善（P<0.05），且觀察組上述氧化應(yīng)激指標(biāo)改善更為明顯（P<0.05）。結(jié)論 杏丁注射液聯(lián)合前列地爾治療慢性腎衰竭的療效顯著，能改善患者的腎功能和氧化應(yīng)激狀態(tài)，具有一定的臨床推廣應(yīng)用價值。

Objective To study the clinical effect of Xingding Injection combined with alprostadil in patients with chronic renal failure. Methods A total of 100 patients with chronic renal failure admitted to Yulin Second Hospital from March 2015 to March 2018 were selected as the study subjects, and randomly divided into control group and observation group, with 50 patients in each group. Patients in the control group were iv administered with Alprostadil Injection, 10 g was added to 100 mL normal saline, once daily. Patients in the observation group were iv administered with Ginkgo Leaf Extract and Dipyridamole Injection on the basis of control group, 20 mL added into 250 mL normal saline, once daily. Both groups were treated for 2 weeks. The clinical efficacy in two groups was observed, and the renal function indexes and oxidative stress function indexes of the two groups before and after treatment were compared. Results After treatment, the effective rate in the control group and observation group was 70.00% and 86.00%, respectively, and the difference between two groups was statistically significant (P<0.05). After treatment, the levels of BUN, 24 h urine protein quantification, and Scr in two groups were significantly decreased (P<0.05), and the indexes in the observation group was significantly lower than those in the control group (P<0.05). After treatment, the levels of SOD, AGEs, MDA, and AOPP in two groups were significantly improved (P<0.05), and the oxidative stress indexes were significantly improved in the observation group (P<0.05). Conclusion Xingding Injection combined with alprostadil is effective in treating chronic renal failure, can improve the renal function and oxidative stress, and has certain clinical application value.

R983