氧化苦參堿具有廣泛的生物活性，如保護(hù)心、肝、肺、腎、腦、血管作用，對(duì)心臟有正性肌力、負(fù)性頻率、抗心律失常作用，還有升高白細(xì)胞，平喘，抗?jié)?，抗纖維化以及鎮(zhèn)靜、催眠、鎮(zhèn)痛等中樞神經(jīng)藥理作用，也具有抗腫瘤、免疫調(diào)節(jié)、抗菌、抗病毒、抗炎等藥理作用。氧化苦參堿是一種親水性很強(qiáng)的弱堿性藥物，易被代謝成苦參堿，尤其在口服給藥時(shí)可被看做為苦參堿的前藥。通過(guò)綜述氧化苦參堿藥動(dòng)學(xué)參數(shù)、體內(nèi)過(guò)程，總結(jié)氧化苦參堿的藥動(dòng)學(xué)研究進(jìn)展，為合理用藥提供參考。

Oxymatrine has a widespread bioactivities, including protection of heart, liver, lung, kidney, brain and blood vessel, and the effects of positive inotropism, negative chronotropism and antiarrhythmia on heart, and promoting leukocytes, antiasthma, antiulcer, anti-fibrogenesis, and central suppression of sedation, hypnogenesis, analgesia, and antitumor, immunoregulation, antibacteria, anti-virus and anti-inflammation. Oxymatrine is a strong hydrophilic and weakly alkaline drug. Oxymatrine is easily transformed into matrine, especially when it is given orally. Oxymatrine can be regarded as a prodrug of matrine. The pharmacokinetic parameters and process in body of oxymatrine are reviewed, and its research advances on pharmacokinetics is summarized, which provides a reference for rational utilization of oxymatrine.

R285.5;R969.1