目的 探討康婦炎膠囊聯(lián)合替硝唑?qū)β殉材夷[患者的臨床療效和各激素水平的影響。方法 選取2017年1月-2019年1月漢中市人民醫(yī)院90例卵巢囊腫患者作為研究對象。根據(jù)就診單雙號將患者分為對照組和觀察組，每組各45例。對照組患者靜脈滴注替硝唑氯化鈉注射液，400 mg，1次/d，經(jīng)期停藥。觀察組患者在對照組的基礎(chǔ)上口服康婦炎膠囊，3粒/次，2次/d，經(jīng)期停藥。兩組均連續(xù)治療2周。觀察兩組患者的臨床療效，同時比較兩組治療前后的中醫(yī)癥狀評分、一氧化氮（NO）、腫瘤壞死因子-α（TNF-α）水平、各激素水平和囊腫直徑。結(jié)果 治療后，觀察組患者總有效率為93.33%，對照組患者總有效率為77.78%，兩組比較存在統(tǒng)計學(xué)差異（P<0.05）。治療后，兩組患者癥狀積分、NO和TNF-α水平均顯著降低（P<0.05）；且觀察組癥狀積分、NO和TNF-α水平均顯著低于對照組（P<0.05）。治療后，兩組患者抗苗勒試管激素（AMH）、孕酮（P）、雌二醇（E2）和囊腫直徑均明顯降低，促黃體生成素（LH）/卵泡雌激素（FSH）顯著升高（P<0.05）；且觀察組各激素水平和囊腫直徑顯著優(yōu)于對照組（P<0.05）。結(jié)論 康婦炎膠囊聯(lián)合替硝唑可有效改善卵巢囊腫患者各激素水平，緩解患者的臨床癥狀，療效確切，在卵巢囊腫治療中具有較高的應(yīng)用價值。

Objective To investigate the clinical effect of Kangfuyan Capsules combined with tinidazole in treatment of ovarian cyst, and the influence of hormone levels. Methods A total of 90 cases patients with ovarian cysts in Hanzhong People's Hospital from January 2017 to January 2019 were selected as research objects. And the patients were divided into the control group and the observation group according to the odd or even number of patients. There were 45 patients in each group. Patients in the control group were iv administered with Tinidazole and Sodium Chloride Injection 400 mg, once daily, and stopped taking the drug during menstruation. Patients in the observation group were po administered with Kangfuyan Capsules on the basis of control group, 3 grains/time, twice daily, menstrual withdrawal. Both groups were treated continuously for 2 weeks. After treatment, the clinical efficacy in two groups was observed, and the TCM symptom scores, the levels of NO and TNF-α levels, hormone levels, and cyst diameter of two groups were compared before and after treatment. Results After treatment, the total effective rate was 93.33% in the observation group and 77.78% in the control group, showing statistical difference between the two groups (P<0.05). After treatment, the symptom scores, NO and TNF-α levels in two groups were decreased (P<0.05). In addition, symptom score, NO and TNF-α levels in the observation group were significantly lower than those in the control group (P<0.05). After treatment, AMH, P, E2, and cyst diameter were significantly decreased in two groups, while LH/FSH was significantly increased (P<0.05). The hormone levels and cyst diameter of the observation group were significantly better than those of the control group (P<0.05). Conclusion Kangfuyan Capsules combined with tinidazole can effectively improve the levels of hormones in patients with ovarian cyst, relieve the clinical symptoms, with a definite curative effect, and has a high application value in the treatment of ovarian cyst.

R984

陜西省自然科學(xué)基礎(chǔ)研究計劃一般項目（2018JQ8035）