目的 探討宮頸癌患者中HNF1A-AS1、HNF1A的表達(dá)及其臨床意義。方法 選取2013年-2018年延安市人民醫(yī)院收集的187例宮頸癌患者的癌組織及對(duì)應(yīng)的癌旁正常組織標(biāo)本，通過實(shí)時(shí)熒光定量PCR檢測宮頸癌患者腫瘤組織中HNF1A-AS1、HNF1A的表達(dá)情況，探討HNF1A-AS1、HNF1A表達(dá)水平與宮頸癌患者臨床特征和生存期之間的關(guān)系。結(jié)果 HNF1A-AS1在宮頸癌組織中高表達(dá)（P=0.022）；HNF1A-AS1高表達(dá)與宮頸癌患者腫瘤分期（P<0.001）、是否原位癌（P=0.013）、是否淋巴結(jié)轉(zhuǎn)移（P=0.002）、是否遠(yuǎn)端轉(zhuǎn)移（P<0.001）以及HPV型別相關(guān)（P=0.006）；HNF1A-AS1高表達(dá)組總體生存率明顯低于HNF1A-AS1低表達(dá)組（χ²=10.33，P=0.002）。HNF1A在宮頸癌組織中高表達(dá)（P=0.044），且HNF1A的相對(duì)表達(dá)量與HNF1A-AS1表達(dá)呈正相關(guān)（P<0.001）；HNF1A高表達(dá)與宮頸癌患者腫瘤分期（P=0.002）、是否原位癌（P=0.007）、是否淋巴結(jié)轉(zhuǎn)移（P=0.005）、是否遠(yuǎn)端轉(zhuǎn)移（P<0.001）以及HPV型別相關(guān)（P=0.003）；HNF1A高表達(dá)組總體生存率明顯低于HNF1A低表達(dá)組（χ²=6.10，P=0.013）。結(jié)論 HNF1A-AS1、HNF1A促進(jìn)宮頸癌發(fā)生和發(fā)展，并與宮頸癌患者生存期相關(guān)。

Objective To investigate the expression and clinical significance of HNF1A-AS1 and HNF1A in patients with cervical cancer.Methods The cancer tissues and corresponding normal adjacent tissues of 187 cervical cancer patients collected in Yan'an People's Hospital from 2013 to 2018 were selected, and the expression levels of HNF1A-AS1 and HNF1A in the tumor tissues of cervical cancer patients were detected by real-time fluorescence quantitative PCR, so as to explore the relationship between the expression of HNF1A-AS1 and HNF1A, and the clinical characteristics, survival time of cervical cancer patients. Results HNF1AAS1 was highly expressed in cervical cancer tissues (P=0.022). High HNF1A-AS1 expression was associated with tumor stage (P<0.001), carcinoma in situ (P=0.013), lymph node metastasis (P=0.002), distal metastasis (P<0.001), and HPV type (P=0.006) in patients with cervical cancer. The overall survival rate of the HNF1A-AS1 high expression group was significantly lower than that of the HNF1A-AS1 low expression group (χ²=10.33, P=0.002). HNF1A was highly expressed in cervical cancer tissues (P=0.044), and the relative expression of HNF1A was positively correlated with the expression of HNF1A-AS1 (P<0.001). High expression of HNF1A was associated with tumor stage (P<0.002), carcinoma in situ (P=0.007), lymph node metastasis (P=0.005), distal metastasis (P<0.001), and HPV type (P=0.003) in patients with cervical cancer. The overall survival rate of the HNF1A-AS1 high expression group was significantly lower than that of the low expression group (χ²=6.10, P=0.013). Conclusion HNF1A-AS1 and HNF1A promote the occurrence and development of cervical cancer, and are related to the survival of cervical cancer patients.

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