目的 研究西地那非聯(lián)合比索洛爾治療頑固性高血壓的臨床療效。方法 選擇2016年1月-2019年1月四川省甘孜藏族自治州衛(wèi)生學(xué)校附屬醫(yī)院治療的150例頑固性高血壓患者作為研究對象，采用抽簽法將患者隨機(jī)分為對照組和觀察組，每組各75例。對照組口服富馬酸比索洛爾片，5 mg/次，1次/d。觀察組在對照組的基礎(chǔ)上口服枸櫞酸西地那非片，50 mg/次，1次/d。兩組均連續(xù)服藥8周。觀察兩組患者的血壓和癥狀療效，同時(shí)比較兩組治療前后的24 h動(dòng)態(tài)血壓。結(jié)果 治療后，觀察組的血壓控制總有效率為85.33%，明顯高于對照組的65.33/%（P<0.05）。治療后，觀察組的癥狀改善總有效率為94.67%，明顯高于對照組的72.00%（P<0.05）。治療后，兩組患者日間舒張壓（d DBP）、日間收縮壓（d SBP）、24 h舒張壓（24 h DBP）、24 h收縮壓（24 h SBP）、夜間舒張壓（n DBP）和夜間收縮壓（n SBP）均顯著降低（P<0.05）；且觀察組的24 h動(dòng)態(tài)血壓水平明顯低于對照組（P<0.05）。結(jié)論 西地那非聯(lián)合比索洛爾對頑固性高血壓患者具有較好的療效，值得應(yīng)用推廣。

Objective To study the effect of sildenafil combined with bisoprolol in treatment of refractory hypertension. Methods 150 patients with intractable hypertension in Affiliated Hospital of Health School, Ganzi Tibetan Autonomous Prefecture, Sichuan Province from January 2016 to January 2019 were selected as study subjects, and randomly divided into control group and observation group by lottery, with 75 patients in each group. Patients in the control group were po administered with Bisoprolol Fumarate Tablets, 5 mg/time,once daily. Patients in the observation group were po administered with Sildenafil Citrate Tablets on the basis of control group, 50 mg/time, once daily. Patients in two group were treated for 8 weeks. The blood pressure and symptom efficacy in two groups were observed, and the dynamic blood pressure at 24 h before and after treatment was compared between two groups. Results After treatment, the total effective rate of blood pressure control in the observation group was 85.33%, which was significantly higher than 65.33/% in the control group (P<0.05). After treatment, the total effective rate of symptom improvement in the observation group was 94.67%, which was significantly higher than 72.00% in the control group (P<0.05). After treatment, D DBP, D SBP, 24 h DBP, 24 h SBP, n DBP and n SBP were significantly decreased in two groups (P<0.05). Moreover, the 24-hour ambulate blood pressure level of the observation group was significantly lower than those of the control group (P<0.05). Conclusion Sildenafil combined with bisoprolol has a good effect on patients with refractory hypertension and is worthy of application and promotion.

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