目的 探討丁苯酞氯化鈉注射液聯(lián)合阿司匹林和氯吡格雷治療急性腦梗死的臨床療效及其對白細(xì)胞介素（IL）-6水平的影響。方法 選擇2014年5月-2018年7月選擇在洛陽石化醫(yī)院診治的急性腦梗死患者120例作為研究對象，根據(jù)入院順序隨機(jī)數(shù)字表法將患者均分為對照組（60例）和觀察組（60例）。對照組患者口服阿司匹林腸溶片，0.3~0.6 g/次，1次/d；硫酸氫氯吡格雷片，負(fù)荷量300 mg后改為75 mg/d治療，1次/d。觀察組在對照組治療的基礎(chǔ)上靜脈注射丁苯酞氯化鈉注射液，25 mg/次，1次/d。兩組均連續(xù)治療14 d。觀察兩組患者的臨床療效，同時比較兩組治療前后的Barthel指數(shù)、生存質(zhì)量評分和IL-6水平。結(jié)果 治療后，觀察組的總有效率為98.3%，顯著高于對照組的90.0%（P<0.05）。治療后，兩組的Barthel指數(shù)和生存質(zhì)量評分均顯著高于治療前（P<0.05），且觀察組Barthel指數(shù)和生存質(zhì)量評分顯著高于對照組（P<0.05）。兩組治療后的血清IL-6水平顯著低于治療前（P<0.05），且觀察組IL-6水平顯著低于對照組（P<0.05）。結(jié)論 丁苯酞氯化鈉注射液聯(lián)合阿司匹林和氯吡格雷治療急性腦梗死能提高療效，抑制IL-6的表達(dá)，提高患者的日常生活能力和生活質(zhì)量。

Objective To investigate the clinical efficacy of Butylphthalide and Sodium Chloride Injection combined with aspirin and clopidogrel in treatment of acute cerebral infarction and its effect on the level of IL-6. Methods A total of 120 patients with acute cerebral infarction treated in Luoyang Petrochemical Hospital from May 2014 to July 2018 were selected as study subjects, and the patients were divided into control group (60 cases) and observation group (60 cases) according to the random number table method of admission order. Patients in the control group were po administered with Aspirin Enteric-coated Tablets, 0.3-0.6 g/time, once daily, and Clopidogrel Hydrogen Sulphate Tablets with a load of 300 mg, then changed to 75 mg/d for once daily. Patients in the observation group were iv administered with Butylphthalide and Sodium Chloride Injection on the basis of control group, 25 mg/time, once daily. Both groups received continuous treatment for 14 days. After treatment, the clinical efficacy in two groups was observed, and the Barthel index, quality of life score, and IL-6 level of two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 98.3%, which was significantly higher than 90.0% of the control group (P<0.05). After treatment, the Barthel index and quality of life score in two groups were significantly higher than those before treatment (P<0.05), and the Barthel index and quality of life score in the observation group were significantly higher than those in the control group (P<0.05). After treatment, the serum IL-6 level in two groups was significantly lower than that before treatment (P<0.05), and the IL-6 level in the observation group was significantly lower than that in the control group (P<0.05). Conclusion Butylphthalide and Sodium Chloride Injection combined with aspirin and clopidogrel in treatment of acute cerebral infarction can improve the therapeutic effect, inhibit the expression of IL-6, and improve the patient's daily life ability and quality of life.

R971