目的 研究復(fù)方谷氨酰胺聯(lián)合柳氮磺吡啶治療潰瘍性結(jié)腸炎的臨床療效。方法 選擇2017年1月-2019年1月榆林市星元醫(yī)院的120例潰瘍性結(jié)腸炎患者作為研究對(duì)象，采用抽簽法隨機(jī)分為對(duì)照組和觀察組，每組各60例。對(duì)照組患者口服柳氮磺吡啶腸溶片，6片/次，3次/d。觀察組患者在對(duì)照組的基礎(chǔ)上口服復(fù)方谷氨酰胺腸溶膠囊，3粒/次，3次/d。兩組均治療4周。觀察兩組患者的臨床療效，比較兩組治療前后的相關(guān)癥狀、評(píng)分情況，以及炎性因子水平。結(jié)果 治療后，觀察組的總有效率為91.67%，明顯高于對(duì)照組的71.67%（P<0.05）。治療后，觀察組的黏液膿血便消失時(shí)間為（10.13±1.27）d，明顯短于對(duì)照組的（19.73±2.45）d（P<0.05）。兩組治療后的疾病活動(dòng)指數(shù)和腹痛程度評(píng)分均明顯降低（P<0.05），且觀察組明顯更低（P<0.05）。兩組治療后的血清白細(xì)胞介素（IL）-6、腫瘤壞死因子-α（TNF-α）、IL-8、超敏C反應(yīng)蛋白（hs-CRP）水平均明顯降低（P<0.05），且觀察組明顯更低（P<0.05）。結(jié)論 復(fù)方谷氨酰胺聯(lián)合柳氮磺吡啶對(duì)潰瘍性結(jié)腸炎的療效較佳，能明顯減輕腹痛程度，改善炎癥因子水平，降低疾病活動(dòng)指數(shù)。

Objective To study the clinical efficacy of compound glutamine combined with sulfasalazine in treatment of ulcerative colitis. Methods A total of 120 patients with ulcerative colitis in the Xing Yuan Hospital of Yulin from January 2017 to January 2019 were selected as the research objects, and randomly divided into control group and observation group by lottery, with 60 patients in each group. Patients in the control group were po administered with Sulfasalazine Enteric-coated Tablets, 6 tablets/time, three times daily. Patients in the observation group were po administered with Compound Glutamine Entersoluble Capsules on the basis of the control group, 3 grains/time, three times daily. Both groups were treated for 4 weeks. After treatment, the clinical efficacy in two groups was observed, and the related symptoms, scores, and inflammatory factor levels in two groups before and after treatment were compared. Results After treatment, the effective rate of the observation group was 91.67%, which was significantly higher than 71.67% of the control group (P<0.05). After treatment, the disappearance time of mucous pus blood in the observation group was (10.13 ±1.27) d, which was significantly shorter than (19.73 ±2.45) d in the control group (P<0.05). After treatment, disease activity index and abdominal pain degree score were significantly reduced in two groups (P<0.05), and were significantly lower in the observation group (P<0.05). After treatment, the serum levels of IL-6, TNF-α, IL-8, and hs-CRP in two groups were significantly decreased (P<0.05), and those indexes in the observation group were significantly lower (P<0.05). Conclusion Compound glutamine combined with sulfasalazine has a better effect on ulcerative colitis, can significantly reduce the degree of abdominal pain, improve the level of inflammatory factors, reduce the disease activity index.

R975