目的 探討谷紅注射液聯(lián)合阿加曲班治療急性腦梗死的療效及其對血清超氧化物歧化酶（SOD）和丙二醛（MDA）水平影響。方法 選取2018年1月-2020年1月保定市第二中心醫(yī)院收治的急性腦梗死患者104例作為研究對象，將患者隨機分為對照組和觀察組，每組各52例。對照組患者靜脈滴注阿加曲班注射液，60 mg阿加曲班注射液以適當量的氯化鈉注射液稀釋，經(jīng)24 h持續(xù)靜脈滴注治療2 d，然后10 mg/次治療5 d，早晚各1次。觀察組在對照組基礎(chǔ)上靜脈滴注谷紅注射液，20 mL/次，溶于氯化鈉注射液250 mL中靜脈滴注，1次/d。兩組患者持續(xù)治療14 d。觀察兩組患者的臨床療效，同時比較兩組治療前后的Barthel指數(shù)（BI）和美國國立衛(wèi)生研究院卒中量表（NIHSS）評分、血清SOD和MDA水平，以及血漿黏度（PV）、全血黏度（WBV）、紅細胞壓積（HCT）、纖維蛋白原（FIB）水平。結(jié)果 治療后，對照組和觀察組總有效率分別80.77%和94.23%，兩組總有效率比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組BI評分顯著升高，NIHSS評分降低（P<0.05）；且觀察組NIHSS評分和BI評分顯著優(yōu)于對照組（P<0.05）。治療后，兩組MDA水平顯著降低，SOD水平顯著升高（P<0.05）；治療后，觀察組血清SOD和MDA水平顯著優(yōu)于對照組（P<0.05）。治療后，兩組PV、WBV、HCT、FIB水平均明顯降低（P<0.05）；治療后，觀察組PV、WBV、HCT、FIB水平顯著低于對照組（P<0.05）。結(jié)論 谷紅注射液聯(lián)合阿加曲班治療急性腦梗死具有較好的臨床療效，能夠改善患者血清SOD和MDA水平，值得臨床推廣應(yīng)用。

Objective To investigate the effect of Guhong injection combined with agatreban on acute cerebral infarction and its effect on serum SOD and MDA levels. A total of 104 patients with acute cerebral infarction admitted to the Second Central Hospital of Baoding City from January 2018 to January 2020 were selected as the research subjects, and the patients were randomly divided into control group and observation group, with 52 cases in each group. Methods Patients in the control group were iv administered with Argatroban Injection, 60 mg Argatroban Injection was diluted with appropriate amount of sodium chloride injection for 24 h continuous intravenous infusion for 2 d, and then 10 mg/time for 5 d, once in the morning and once in the evening. Patients in the observation group were iv administered with Guhong Injection intravenously, 20 mL/time, dissolved in 250 mLsodium chloride injection intravenously, once daily. Patients in two groups were treated for 14 d. Clinical efficacy of two groups was observed, and the BI score, NIHSS score, serum levels of SOD, MDA, PV, WBV, HCT, and FIB before and after treatment were compared. Results After treatment, the total effective rate of the control group and the observation group was 80.77% and 94.23%, respectively, and the total effective rate of the two groups was statistically significant (P<0.05). After treatment, BI score in two groups was significantly increased, while NIHSS score was decreased (P<0.05). And the NIHSS and BI scores in the observation group were significantly better than those in the control group (P<0.05). After treatment, the levels of PV, WBV, HCT and FIB in two groups were significantly decreased (P<0.05). After treatment, the levels of PV, WBV, HCT and FIB in observation group were significantly lower than those in control group (P<0.05). After treatment, the MDA level was significantly decreased, but the SOD level was significantly increased (P<0.05). After treatment, the levels of SOD and MDA in serum of observation group were significantly better than those of control group (P<0.05). Conclusion Guhong Injection combined with agartreban in treatment of acute cerebral infarction has a good clinical effect, can improve serum SOD and MDA levels, worthy of clinical application.

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