黃連多糖是毛茛科植物黃連、三角葉黃連和云連的藥效成分之一，具有抗氧化、降血糖、減輕炎癥反應(yīng)和神經(jīng)保護(hù)等廣泛的藥理作用。其抗氧化可能是通過提高機(jī)體抗氧化酶來發(fā)揮作用；其降血糖作用機(jī)制較多，包括抑制α-淀粉酶、提高胰島素敏感性和促進(jìn)葡萄糖攝取；其抗炎作用可能與活化巨噬細(xì)胞和抑制炎癥反應(yīng)酪氨酸激酶2/信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子3（JAK2/STAT3）信號通路中p-JAK2、p-STAT3的表達(dá)有關(guān)；可能通過抑制氨基末端激酶（JNK）介導(dǎo)的鼠嗜鉻神經(jīng)瘤細(xì)胞（PC12）凋亡信號通路來發(fā)揮神經(jīng)保護(hù)作用。對近年來有關(guān)黃連多糖的藥理作用等文獻(xiàn)進(jìn)行綜述，為進(jìn)一步研究和應(yīng)用提供參考。

Coptis Chinensis polysaccharide is one of the effective components of Coptis chinensis Franch., C. deltoidea C.Y.Cheng et Hsiao. and C. teeta Wall. in the Ranunculaceae family. It has a wide range of pharmacological effects such as antioxidant, hypoglycemic, anti-inflammatory and neuroprotective effects. Relevant studies have found that its antioxidant may be exerted by increasing the body's antioxidant enzymes; its hypoglycemic has many mechanisms, such as:inhibiting α -amylase, improving insulin sensitivity and promoting glucose uptake; its anti-inflammatory effect may be related to activation Macrophages are related to the expression of p-JAK2 and p-STAT3 in the tyrosine kinase 2/signal transduction and transcription activator 3(JAK2/STAT3) signaling pathway that inhibits inflammation. For neuroprotection, studies have found that CCP may play a role by inhibiting the JNK-mediated apoptosis signaling pathway in mouse pheochromocytoma cells (PC12). This article reviewed studies on the extraction and purification, monosaccharide composition analysis, and pharmacological effects of Coptis Chinensis polysaccharide in recent years, and provided a perspective on further research and application of it.

R285.5

國家自然科學(xué)基金重點(diǎn)項(xiàng)目（82030116）；國家重大新藥創(chuàng)制專項(xiàng)（2017ZX09301012-001）