潰瘍性結(jié)腸炎（UC）是一種難治性慢性非特異性炎癥腸道疾病，西醫(yī)對UC發(fā)病機制并未完全闡明，目前尚無根治措施。近年來研究發(fā)現(xiàn)許多中藥和藥食同源的植物多糖治療UC效果較好，且副作用小。本文主要對藥食同源植物多糖黃芪多糖、當歸多糖、馬齒莧多糖、枸杞多糖、香菇多糖、猴頭菌多糖等調(diào)節(jié)腸道微生態(tài)平衡、調(diào)節(jié)腸道免疫功能、抗炎、抗氧化、改善腸黏膜功能治療UC的作用和機制進行綜述，以期為UC的臨床治療和新藥開發(fā)提供新思路和理論依據(jù)。

Ulcerative colitis (UC) is a refractory chronic non-specific inflammatory bowel disease. Western medicine has not fully clarified the pathogenesis of UC, and there is no radical cure so far. In recent years, studies have found that many Chinese medicines and plant polysaccharides with medicine and food homology exhibited better effects in treating UC and have fewer side effects. In this article, the pharmacological effects and mechanisms of plant polysaccharides with medicine and food homology, such as astragalus polysaccharide, angelica polysaccharide, purslane polysaccharide, wolfberry polysaccharide, lentinan and hericium erinaceus polysaccharide in the treatment of UC via regulating the intestinal microecological balance, regulating the intestinal immune function, anti-inflammatory, anti-oxidation, and improving the intestinal mucosal function were reviewed. The main purpose of this article is to provide new ideas and theoretical basis for the clinical treatment and new drug development of UC.

R944.5

國家自然科學基金資助項目（81974509）；湖北省自然科學基金資助項目（2017CFB273）