肌萎縮性側(cè)索硬化癥（Amyotrophic lateral sclerosis，ALS）是運(yùn)動(dòng)神經(jīng)元病變相關(guān)疾患中最常見的類型之一，致殘致死率高，嚴(yán)重影響患者生活質(zhì)量，給家庭帶來(lái)了沉重的負(fù)擔(dān)。其主要病理機(jī)制為多種因素導(dǎo)致運(yùn)動(dòng)神經(jīng)元損傷變性，保護(hù)神經(jīng)元乃行之有效的治療方法。補(bǔ)益類中藥杜仲來(lái)源于杜仲Eucommia ulmoides的干燥樹皮，現(xiàn)代藥理研究證實(shí)其有效成分具有神經(jīng)保護(hù)、抗氧化應(yīng)激等作用而被廣泛運(yùn)用于臨床神經(jīng)退行性疾患的防治。以當(dāng)前對(duì)ALS發(fā)病機(jī)制的主流認(rèn)識(shí)為出發(fā)點(diǎn)，探討杜仲提取物及有效成分防治ALS的可行性，以期為杜仲防治ALS方面的開發(fā)應(yīng)用有所裨益。

Amyotrophic lateral sclerosis (ALS) is one of the most common types of motor neuron disease-related diseases. It has a high disability and fatality rate, which seriously affects the quality of life of patients and brings a heavy burden to families. The main pathological mechanism is that a variety of factors cause motor neuron damage and degeneration. Protecting neurons is an effective treatment. Eucommia ulmoides is a traditional Chinese medicinal material for tonics in my country. Modern pharmacology has confirmed that its active ingredients have neuroprotective and anti-oxidative stress effects and are widely used in the prevention and treatment of clinical neurodegenerative diseases. Based on the current mainstream understanding of the pathogenesis of ALS, this article discusses the feasibility of Eucommia ulmoides and its active ingredients in the prevention and treatment of ALS, hoping to benefit the development and application of Eucommia ulmoides in the prevention and treatment of ALS in the future.

R285.5

蘭州市創(chuàng)新人才項(xiàng)目（2018-RC-99）；國(guó)家自然科學(xué)基金資助項(xiàng)目（81760877）；甘肅省中醫(yī)藥管理局重點(diǎn)課題（GZKZ-2020-3）；甘肅省中醫(yī)藥項(xiàng)目（GZK-2019-2）