目的探討益中生血片聯(lián)合琥珀酸亞鐵片治療重度缺鐵性貧血的臨床療效。方法選擇2019年1月-2020年1月于河北北方學(xué)院附屬第一醫(yī)院就診的120例重度缺鐵性貧血患者作為研究對象，采用隨機(jī)數(shù)字表法將患者分為對照組和觀察組，每組60例。對照組患者餐后服用琥珀酸亞鐵片，1片/次，3次/d。觀察組在對照組基礎(chǔ)上餐后服用益中生血片，2片/次，3次/d，4周為1個療程，兩組患者均治療1個療程。觀察兩組患者的臨床療效，同時比較兩組治療前后的中醫(yī)證候積分，外周血紅細(xì)胞（RBC）、血紅蛋白（Hb）、平均紅細(xì)胞體積（MCV）、平均紅細(xì)胞血紅蛋白量（MCH）、紅細(xì)胞平均血紅蛋白濃度（MCHC）、網(wǎng)織紅細(xì)胞血紅蛋白（Ret-He）含量，以及血清鐵離子（Fe）和血清鐵蛋白（SF）水平。結(jié)果治療后，對照組和觀察組的總有效率分別為83.33%、95.00%，兩組總有效率比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者中醫(yī)證候積分均降低（P<0.05），且觀察組明顯低于對照組（P<0.05）。治療后，兩組患者RBC、Hb、MCV、MCH、MCHC、Ret-He水平均顯著升高（P<0.05）；且觀察組外周血象水平明顯高于對照組（P<0.05）。治療后，兩組患者血清Fe、SF水平均升高（P<0.05），且觀察組血清Fe、SF水平明顯高于對照組（P<0.05）。結(jié)論益中生血片聯(lián)合琥珀酸亞鐵片對重度缺鐵性貧血患者療效較好，可有效改善患者外周血象，提高網(wǎng)織紅細(xì)胞血紅蛋白含量并改善鐵代謝水平。

Objective To investigate the clinical effect of Yizhong Shengxue Tablets combined with Ferrous Succinate Tablets in treatment of severe iron deficiency anemia. Methods A total of 120 patients with severe iron deficiency anemia who were treated in the First Affiliated Hospital of Hebei North University from January 2019 to January 2020 were selected as the research subjects. The patients were divided into control group and observation group by random number table method, with 60 cases in each group. Patients in the control group were po administered with Ferrous Succinate Tablets after meal, 1 tablet/time, three times daily. Patients in the observation group were po administered with Yizhong Shengxue Tablets on the basis of control group after meal, 2 tablets/ time, three times daily, four weeks as a course of treatment. Patients in both groups were treated for a course of treatment. To observe the clinical efficacy of two groups, and TCM syndrome integral, the levels of peripheral blood RBC, Hb, MCV, MCH, MCHC, Ret-He, and serum iron and ferritin before and after treatment were compared. Results After treatment, the total effective rate of the control group and the observation group was 83.33% and 95.00%, respectively, and the difference of total effective rate between two groups was statistically significant (P < 0.05). After treatment, TCM syndrome scores in two groups were decreased (P < 0.05), and observation group was significantly lower than control group (P < 0.05). After treatment, the levels of RBC, Hb, MCV, MCH, MCHC and Ret-He in two groups were significantly increased (P < 0.05). And the levels of peripheral blood in observation group was significantly higher than that in control group (P < 0.05). After treatment, the levels of serum Fe and SF in two groups were increased (P < 0.05), and the levels of serum Fe and SF in observation group were significantly higher than those in control group (P < 0.05). Conclusion Yizhong Shengxue Tablets combined with Ferrous Succinate Tablets has a good effect on patients with severe iron deficiency anemia, which can effectively improve peripheral blood image, increase reticulocyte hemoglobin content and improve iron metabolism level.

R973

河北省醫(yī)學(xué)科學(xué)研究重點課題計劃（2017804）；張家口市2019年度市級科技計劃項目（1921135H）