目的探討羚羊角顆粒聯(lián)合奧卡西平治療兒童癲癇的療效。方法選取2017年5月-2019年5月在濰坊市婦幼保健院兒科住院治療的46例癲癇患兒為研究對象，根據(jù)隨機數(shù)字法將患兒分為對照組（23例）和觀察組（23例）。對照組患兒口服奧卡西平片30 mg/（kg·d），1次/d。觀察組在對照組的基礎上口服羚羊角顆粒，5 g/次，2次/d。兩組均連續(xù)服用15 d。觀察兩組患者的臨床療效，同時比較兩組治療前后的腦電圖波段占比情況及血清白細胞介素6（IL-6）、腫瘤壞死因子-α（TNF-α）、基質(zhì)金屬蛋白酶-9（MMP-9）、高遷移率蛋白1（HMGB1）水平。結(jié)果治療后，對照組總有效率為69.57%，顯著低于觀察組的95.66%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組癲癇發(fā)作頻率和持續(xù)時間均顯著降低（P<0.05）；治療后，觀察組發(fā)作頻率和持續(xù)時間顯著低于對照組（P<0.05）。治療后，兩組患者腦電圖波段δ波、θ波百分比顯著降低，而α波、β波百分比顯著升高（P<0.05）；觀察組患者腦電圖波段δ波、θ波百分比低于對照組，α波、β波百分比高于對照組（P<0.05）。治療后，兩組IL-6、TNF-α、MMP-9、HMGB1水平均顯著降低（P<0.05）；且觀察組患者的IL-6、TNF-α、MMP-9、HMGB1水平顯著低于對照組（P<0.05）。治療期間，觀察組患者的不良反應總發(fā)生率8.69%，低于對照組的34.78%（P<0.05）。結(jié)論羚羊角顆粒與奧卡西平聯(lián)合治療癲癇患兒臨床的效果顯著，可明顯控制癲癇發(fā)作，減少腦電圖中癇性放電，患兒智力水平和生活質(zhì)量得到提高，在臨床上值得推廣。

Objective To investigate the efficacy of Lingyangjiao Granules combined with oxcarbazepine in treatment of pediatric epilepsy. Methods A total of 46 children with epilepsy who were hospitalized in the W.F. Maternal and Child Health Hospital from May 2017 to May 2019 were selected as the research subjects. According to random number method, the children were divided into control group (23 cases) and observation group (23 cases). Children in the control group were po administered with Oxcarbazepine Tablets 30 mg/(kg·d), once daily. Children in the observation group were po administered with Lingyangjiao Granules on the basis of control group, 5 g/time, twice daily. Both groups were treated for 15 d continuously. The clinical efficacy of two groups was observed, and the ratio of EEG bands and serum levels of IL-6, TNF-α, MMP-9, and HMGB1 before and after treatment were compared. Results After treatment, the total effective rate of the control group was 69.57%, significantly lower than 95.66% of the observation group, and the difference between two groups was statistically significant (P < 0.05). After treatment, the frequency and duration of seizures in two groups were significantly decreased (P < 0.05). After treatment, the frequency and duration of seizure in observation group were significantly lower than those in control group (P < 0.05). After treatment, the percentages of δ wave and θ wave in EEG band were significantly decreased, while the percentages of α wave and β wave were significantly increased (P < 0.05). The percentage of δ wave and θ wave in EEG band in observation group was lower than that in control group, and the percentage of α wave and β wave in observation group was higher than that in control group (P < 0.05). After treatment, the levels of IL-6, TNF-α, MMP-9 and HMGB1 in two groups were significantly decreased (P < 0.05). The levels of IL-6, TNF-α, MMP-9 and HMGB1 in observation group were significantly lower than those in control group (P < 0.05). During treatment, the total incidence of ADR in observation group was 8.69%, which was lower than 34.78% in control group (P < 0.05). Conclusion Lingyangjiao Granules combined with oxcarbazepine has a significant clinical effect in treatment of children with epilepsy, which can significantly control epileptic seizures, reduce epileptic discharge in electroencephalogram, and improve the intelligence level and quality of life of children, which is worthy of promotion in clinical practice.

R971