氧化苦參堿對心臟具有正性肌力和負性頻率作用，對心肌自律性：在低濃度時降低、高濃度時提高自律性。氧化苦參堿能顯著降低變?yōu)槁磻毎男氖壹〉淖月尚?。其正性肌力作用的機制系促進外鈣內流，從而促進心肌細胞內的肌漿網鈣大量釋放所致。而負性自律性和負性頻率產生的機制與阻滯鈉離子通道有關。因此氧化苦參堿能防治心力衰竭、心肌缺血和各種化學品引起的心律失常。

Matrine has positive inotropic action and negative chronotropic action,and in myocardial automaticity low concentration decreasing and high concentration increasing automaticity. Oxymatrine decreases myocardial automaticity of becoming slow response cells. The mechanisms of positive inotropic action is promoting extracellular calcium to flow into intracellular. thus promoting Ca²⁺ release of sarcoplasmic reticulum in myocardium. The mechanism of negative automaticity and negative chronotropic action may relate to blocking Na+ channel, oxymatrine can prevent and treat arrhythmia induced by heart failure, myocardial ischemia, and various chemicals.

R285.5