目的 觀察莫家清寧丸治療實熱內(nèi)結(jié)型不完全性腸梗阻的療效及對血清血管活性腸肽（VIP）、C反應(yīng)蛋白（CRP）、胃動素（MTL）的影響。方法 選取2019年5月-2020年12月平煤神馬醫(yī)療集團總醫(yī)院治療的302例實熱內(nèi)結(jié)型不完全性腸梗阻患者作為研究對象，按照治療方法將全部患者分為對照組（151例）和觀察組（151例）。對照組患者給予禁食水、糾正水電解質(zhì)紊亂，持續(xù)胃腸減壓、護胃、抗炎、解痙、鎮(zhèn)痛等基礎(chǔ)治療。觀察組在對照組的基礎(chǔ)上口服莫家清寧丸，6 g/次，1次/d。兩組均治療7 d。觀察兩組的臨床療效和癥狀改善情況，同時比較兩組治療前后的VIP、CRP、MTL水平及中醫(yī)證候積分。結(jié)果 治療后，對照組總有效率為80.42%，顯著低于觀察組的95.07%（P<0.05）。治療后，與對照組比較，觀察組腹痛緩解時間、腹脹緩解時間、首次排氣時間、住院時間均明顯縮短（P<0.05）。治療后，兩組血清VIP、CRP水平均明顯降低，MTL水平明顯升高（P<0.05）；且觀察組VIP、CRP水平低于對照組，MTL水平明顯高于對照組（P<0.05）。治療后，兩組中醫(yī)癥候積分明顯降低（P<0.05），且觀察組明顯低于對照組（P<0.05）。結(jié)論 莫家清寧丸可有效改善實熱內(nèi)結(jié)型不完全腸梗阻患者的臨床癥狀，促進胃腸激水平恢復(fù)，減輕炎癥水平，療效顯著。

Objective To observe the curative effect of Mojia Qingning Pills in treatment of incomplete intestinal obstruction of excess-heat accumulation type and its effect on serum VIP, CRP, and MTL. Methods A total of 302 patients with incomplete intestinal obstruction of excess-heat accumulation type treated by Pingmei Shenma Medical Group General Hospital from May 2019 to December 2020 were selected as the research subjects, and all the patients were divided into control group (151 cases) and observation group (151 cases) according to the treatment methods. Patients in the control group were given basic treatment. Patients in the observation group were po administered with Mojia Qingning Pills on the basis of control group, 6 g/time, once daily. Both groups were treated for 7 d. The clinical efficacy and symptom improvement of two groups were observed, and the levels of VIP, CRP, and MTL, and TCM syndrome scores were compared before and after treatment. Results After treatment, the total effective rate of the control group was 80.42%, which was significantly lower than 95.07% of the observation group (P<0.05). After treatment, compared with the control group, the relief time of abdominal pain, the relief time of abdominal distension, the first exhaust time, and the hospitalization time in the observation group were significantly decreased (P<0.05). After treatment, the serum VIP and CRP levels in two groups were significantly decreased, while the MTL level was significantly increased (P<0.05). The levels of VIP and CRP in the observation group were lower than those in the control group, and the levels of MTL in the observation group were significantly higher than those in the control group (P<0.05). After treatment, the scores of TCM symptoms in the two groups were significantly decreased (P<0.05), and the observation group was significantly lower than the control group (P<0.05).Conclusion Mojia Qingning Pills can effectively improve the clinical symptoms of patients with incomplete intestinal obstruction of excess-heat accumulation type, promote the recovery of gastrointestinal irritability level, reduce the level of inflammation, and have significant curative effect.

R982

河南省醫(yī)學(xué)科技攻關(guān)計劃省部共建青年項目（182102310149）