萊菔硫烷是一種富含于十字花科植物的天然活性成分，對于脂肪肝具有良好的防治作用。藥理研究發(fā)現(xiàn)萊菔硫烷通過減少脂肪積累、緩解線粒體功能障礙以及恢復(fù)氧化平衡緩解飲食因素引起的代謝相關(guān)脂肪性肝病；通過加速體內(nèi)乙醛的代謝、減輕細(xì)胞內(nèi)的氧化應(yīng)激、修復(fù)腸道屏障功能緩解酒精性脂肪肝。萊菔硫烷緩解代謝相關(guān)脂肪性肝病的作用機(jī)制研究較多，并體現(xiàn)出明顯的優(yōu)勢，綜述其調(diào)節(jié)脂肪肝的藥理作用研究進(jìn)展，以期為新藥研發(fā)提供理論依據(jù)。

Sulforaphane is a natural active ingredient rich in cruciferous plants and has a good preventive effect on fatty liver disease (FLD). Pharmacological studies have found that SFN reduces fat accumulation, relieves mitochondrial dysfunction, and restores oxidative balance to alleviate metabolic-associated fatty liver disease (MAFLD) caused by dietary factors; accelerates the metabolism of acetaldehyde in the body, reduces intracellular oxidative stress, and repairs the intestinal barrier function to relieve alcoholic liver disease. There are many studies on the mechanism of SFN in relieving MAFLD, and it has shown obvious advantages. The research progress of its pharmacological effect on regulating FLD is reviewed in order to provide a theoretical basis for the research and development of new drugs.

R285.5

國家自然科學(xué)基金面上項(xiàng)目（81573135）；黑龍江中醫(yī)藥大學(xué)優(yōu)秀青年學(xué)術(shù)帶頭人支持計(jì)劃項(xiàng)目