丙戊酸在臨床上主要用于各型癲癇的治療，但其體內(nèi)代謝個體差異大，有效血藥濃度達(dá)標(biāo)率低。有效血藥濃度是保證療效和減少毒副作用的重要前提，臨床常采取血藥濃度監(jiān)測來提高丙戊酸血藥濃度達(dá)標(biāo)率，以保證癲癇治療的有效性和安全性。從丙戊酸血藥濃度監(jiān)測方法、丙戊酸血藥濃度與療效的相關(guān)性、丙戊酸血藥濃度與不良反應(yīng)的相關(guān)性和丙戊酸血藥濃度影響因素4方面做一綜述，為開展有關(guān)丙戊酸血藥濃度監(jiān)測及合理用藥提供參考。

Valproic acid is mainly used in the clinical treatment of various types of epilepsy, but there are great differences in the process of individual in vivo, and the effective blood concentration is low to meet the standard rate. The effective blood concentration is an important premise to ensure the efficacy and reduce the toxic and side effects. In order to ensure the effectiveness and safety of epilepsy treatment, plasma concentration monitoring is often adopted to improve the compliance rate of valproic acid plasma concentration.In this paper, the monitoring methods of valproic acid plasma concentration, the correlation between valproic acid plasma concentration and efficacy, the correlation between valproic acid plasma concentration and adverse reactions, and the influencing factors of valproic acid plasma concentration were reviewed in order to provide reference for the development of valproic acid plasma concentration monitoring and rational drug use.

R969

云南省衛(wèi)生科技計劃項目（2018NS0170）