醛糖還原酶抑制劑是治療糖尿病并發(fā)癥的重要藥物之一，可通過抑制體內(nèi)高血糖狀態(tài)下被激活的多元醇通路中醛糖還原酶的活性而減少山梨醇的蓄積，預(yù)防和延緩糖尿病及其并發(fā)癥的發(fā)生發(fā)展。中藥來源的醛糖還原酶抑制劑來源更加廣泛，顯示了良好的應(yīng)用前景。綜述了2010—2020年報(bào)道的來源于中藥的醛糖還原酶抑制劑及其在改善糖尿病并發(fā)癥癥狀等方面取得的研究進(jìn)展，主要包括生物堿類、黃酮類、酚酸類、皂苷類、多糖類，以及中藥提取物，以期為新藥研發(fā)提供依據(jù)。

Aldose reductase inhibitors are one of the important drugs for the treatment of diabetic complications, which can reduce the accumulation of sorbitol by inhibiting aldose reductase in the polyol pathway activated under the condition of hyperglycemia in the body, and prevent and delay the occurrence and development of diabetes and its complications. Aldose reductase inhibitors derived from traditional Chinese medicine are more widely available, which shows a good application prospect. The aldose reductase inhibitors derived from traditional Chinese medicine and their research progress in improving the symptoms of diabetes complications from 2010 to 2020 are reviewed in order to provide the basis for the research and development of new drugs. The aldose reductase inhibitors in this review mainly include alkaloids, flavonoids, phenolic acids, saponins, polysaccharides and several herbal extracts.

R285.5

國(guó)家自然科學(xué)基金資助項(xiàng)目（81973565）；國(guó)家重大新藥創(chuàng)制專項(xiàng)（2017ZX09301005）