附子來(lái)源于毛茛科植物烏頭Aconitum carmichaeli Debx.，最主要的毒性反應(yīng)表現(xiàn)為心臟毒性和神經(jīng)毒性，其中心臟是主要的靶器官之一。目前普遍認(rèn)為附子所致心臟毒性是由雙酯型二萜生物堿直接或間接作用于心臟的結(jié)果，其毒性機(jī)制與Ca²⁺超載、脂質(zhì)過(guò)氧化反應(yīng)、細(xì)胞凋亡以及迷走神經(jīng)興奮性增高有關(guān)。研究發(fā)現(xiàn)附子與其他傳統(tǒng)中草藥配伍能通過(guò)影響體內(nèi)代謝過(guò)程、抗Ca²⁺超載、抗氧化應(yīng)激、抗凋亡等機(jī)制發(fā)揮減毒增效作用。就近年來(lái)國(guó)內(nèi)外對(duì)附子心臟毒性及配伍減毒增效相關(guān)機(jī)制的研究進(jìn)展進(jìn)行綜述，以期為附子的深入研究和臨床安全用藥提供參考。

Aconite is from Aconitum carmichaeli, the main toxic reactions of aconite are cardiotoxicity and neurotoxicity, among which the heart is one of the most important target organs. At present, it is generally believed that the aconite-induced cardiotoxicity is caused by the direct or indirect action of diester diterpenoid alkaloids on the heart, and the toxic mechanism may be related to Ca²⁺ overload,lipid peroxidation, cell apoptosis and increased vagus nerve excitability. It is found that the compatibility of aconite with other traditional Chinese herbal medicines can play a role in attenuation and synergy by influencing the metabolic in vivo, decrease of intracellular Ca²⁺ overload, antioxidative stress, anti-apoptotic. In this paper, the research progress on cardiotoxicity of aconite and related mechanisms of attenuation and synergy of compatibility at home and abroad were reviewed in recent years, providing reference for further study and clinical safe medication of aconite.

R285.5

黑龍江省自然科學(xué)基金（H2015017）；哈爾濱市科技創(chuàng)新人才研究專(zhuān)項(xiàng)基金項(xiàng)目（2016RAQYJ186）；黑龍江省教育廳面上項(xiàng)目（12521510）