細胞焦亡是近年來證實的一種新的程序性細胞死亡方式，由消化道皮膚素介導，表現為細胞不斷脹大直至細胞膜破裂，導致細胞內容物的釋放進而激活強烈的炎癥反應，導致細胞程序性壞死。細胞焦亡的主要通路包含依賴半胱天冬氨酸蛋白酶（caspase）-1的經典通路和依賴caspase-4、5、11的非經典通路。細胞焦亡在原發(fā)性肝癌的癌前病變以及發(fā)展過程中起重要作用，歸納總結了細胞焦亡的分子機制及其在原發(fā)性肝癌治療中的研究進展，以期為原發(fā)性肝癌的診斷、治療以及新藥研發(fā)提供新的依據。

Pyroptosis is a new type of programmed cell death that has been confirmed in recent years. It is mediated by digestive tract dermatans, which manifests itself as the continuous expansion of cells until the cell membrane ruptures, leading to the release of cell contents and activating a strong inflammatory response. Lead to programmed cell necrosis. The main pathways of pyroptosis include the classical pathways dependent on caspase-1 and the non-classical pathways dependent on caspase-4, 5, and 11. Cell pyroptosis plays an important role in the precancerous lesions and development of primary liver cancer. The molecular mechanism of pyroptosis and its research progress in the treatment of primary liver cancer are summarized, with a view to the diagnosis of primary liver cancer, treatment and new drug development to provide new basis.

國家自然科學基金資助項目（81774132）