蛋白多肽類藥物脂質體是將蛋白多肽類藥物用脂質體包封后形成的載藥脂質體，具有靶向、緩釋、良好的穩(wěn)定性等優(yōu)點。綜述了2000年以來中國專利申請中涉及的新型蛋白多肽類藥物脂質體，包括凝膠型脂質體、前體脂質體、長循環(huán)脂質體、免疫脂質體、柔性脂質體、pH敏感脂質體、配體修飾脂質體、磁性納米脂質體、多囊脂質體，為繼續(xù)開發(fā)新型的蛋白多肽類藥物脂質體提供新的思路。

Protein polypeptide drug liposome are drug-loaded liposome formed by encapsulating protein polypeptide drug in liposome, which has the advantages of targeting, sustained release and good stability. The novel protein polypeptide drug liposome involved in Chinese patent applications including gel-type liposome, proliposome, long-circulating liposome, immunoliposome, flexible liposome, pH-sensitive liposome, ligand-modified liposome, magnetic nano-liposome, multivesicular liposome since 2000 were reviewed, in order to provide new ideas for the development of protein polypeptide drug liposome.