中藥抗炎在近年來已成為一個重要的研究領域，中藥制劑的抗炎臨床研究已經取得了一定進展，但具體活性成分及作用機制仍需進一步明確。斑馬魚由于其獨特的生物學優(yōu)勢，目前已被廣泛應用于中藥抗炎活性的篩選。綜合近年來國內外有關斑馬魚模型在中藥抗炎領域的報道，從已構建的斑馬魚炎癥模型、斑馬魚模型中的炎癥介質、斑馬魚模型在中藥抗炎藥物篩選中的應用3個方面對斑馬魚炎癥模型及其在中藥抗炎領域的研究進展進行綜述，以期為模式生物斑馬魚在中藥抗炎領域的研究應用提供新思路，為抗炎中藥的開發(fā)與利用提供借鑒參考。

The anti-inflammatory properties of traditional Chinese medicine have become an important research area in recent years. At present, the anti-inflammatory clinical research of traditional Chinese medicine has made some progress, but the active ingredient and specific mechanism still needs to be further clarified. Due to its unique biological advantages, zebrafish has been widely used in the anti-inflammatory field of traditional Chinese medicine. This review synthesizes domestic and foreign reports on zebrafish models in the anti-inflammatory field of traditional Chinese medicine in recent years, and comprehensively reviews the recent advances of zebrafish models in this field from three aspects: the first one is different inflammation models of zebrafish, the second one is mediators of inflammation in zebrafish, and the last one is application of zebrafish in screening of anti-inflammatory drugs in traditional Chinese medicine. It will provide a new idea for the application of zebrafish in the anti-inflammatory field of traditional Chinese medicine and a reference for development and utilization of anti-inflammatory Chinese medicine.

R965.1

國家重點研發(fā)計劃（2018YFC1707300）；齊魯工業(yè)大學（山東省科學院）科教產融合創(chuàng)新試點工程項目（2020KJC-ZD08）；濟南市“高校20條”資助項目（2020GXRC053）