目的 探討荊防顆粒聯(lián)合阿奇霉素治療成人支原體肺炎的臨床療效。方法 選取2020年2月—2021年5月在臨沂市人民醫(yī)院治療的成人支原體肺炎患者112例作為研究對(duì)象，按照治療方式將患者分為對(duì)照組與觀察組，每組各56例。對(duì)照組靜脈滴注注射用阿奇霉素，0.5 g/次，1次/d。觀察組在對(duì)照組基礎(chǔ)上口服荊防顆粒，1袋/次，3次/d。兩組均用藥14 d。觀察兩組患者的臨床療效和臨床癥狀消失時(shí)間，比較兩組治療前后的白細(xì)胞介素-6（IL-6）、腫瘤壞死因子（TNF-α）、降鈣素原（PCT）的水平。結(jié)果 治療后，觀察組總有效率為91.07%，顯著高于對(duì)照組的76.78%，兩組總有效率比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，觀察組患者體溫恢復(fù)時(shí)間、咳嗽消失時(shí)間、肺部啰音消失時(shí)間、肺部陰影消失時(shí)間均短于對(duì)照組（P<0.05）。治療后，兩組患者的血清IL-6、IL-10、TNF-α水平均顯著降低（P<0.05）；治療后，觀察組血清IL-6、IL-10、TNF-α水平顯著低于對(duì)照組（P<0.05）。結(jié)論 荊防顆粒聯(lián)合阿奇霉素治療成人支原體肺炎的臨床療效確切，更有利于臨床癥狀的改善，且安全性較高，值得臨床推廣應(yīng)用。

Objective To investigate the clinical efficacy of Jingfang Granules combined with azithromycin in treatment of adult mycoplasma pneumonia. Methods A total of 112 adult patients with mycoplasma pneumonia hospitalized in the Linyi People's Hospital from February 2020 to May 2021 were selected as the research subjects. According to the treatment methods, the patients were divided into control group and observation group, with 56 patients in each group. Patients in the control group were iv administered with Azithromycin for Injection, 0.5 g/time, once daily. Patients in the observation group were po administered with Jingfang Granules, 1 bag/time, 3 times daily. Both groups were treated for 14 days. The clinical efficacy and symptom disappearance time of two groups were observed, and the levels of IL-6, TNF-α, and PCT before and after treatment were compared between two groups. Results After treatment, the total effective rate of the observation group was 91.07%, which was significantly higher than 76.78% of the control group, and the difference of total effective rate between two groups was statistically significant (P < 0.05). After treatment, the recovery time of body temperature, disappearance time of cough, disappearance time of lung rales, and disappearance time of lung shadow in observation group were all earlier than those in control group (P < 0.05). After treatment, the levels of serum IL-6, IL-10, and TNF-α in two groups were significantly decreased (P < 0.05). After treatment, the levels of serum IL-6, IL-10 and TNF-α in observation group were significantly lower than those in control group (P < 0.05). Conclusion Jingfang Granules combined with azithromycin in treatment of adult mycoplasma pneumonia has a definite clinical effect, is more conducive to the improvement of clinical symptoms, and the safety is high, worthy of clinical application.

R974

國家重點(diǎn)研發(fā)計(jì)劃（2019YFC1711200）