目的 分析丁苯酞軟膠囊對(duì)中重度腦白質(zhì)疏松患者認(rèn)知功能、血清血管內(nèi)皮生長因子（VEGF）、血管生成素-2（Ang-2）、S100β、神經(jīng)元特異性烯醇化酶（NSE）水平的影響。方法 選取2019年9月—2020年9月滄州市中心醫(yī)院收治的中重度腦白質(zhì)疏松患者98例作為研究對(duì)象，按治療方法將患者分為對(duì)照組和觀察組，每組各49例。對(duì)照組患者給予常規(guī)治療，包括常規(guī)監(jiān)測(cè)血壓、血糖等相關(guān)危險(xiǎn)因素，給予對(duì)癥處理。觀察組在對(duì)照組治療的基礎(chǔ)上口服丁苯酞軟膠囊，2粒/次，3次/d，兩組共治療12周。比較兩組Van Swieten量表分級(jí)情況，認(rèn)知功能，血清VEGF、Ang-2、S100β、NSE水平，大腦中動(dòng)脈血流速度和PI值。結(jié)果 治療后兩組Van Swieten量表分級(jí)情況均優(yōu)于治療前（P<0.05），且觀察組Van Swieten量表分級(jí)情況優(yōu)于對(duì)照組（P<0.05）。治療后，兩組血清VEGF、Ang-2水平均高于治療前，S100β、NSE水平均低于治療前（P<0.05）；且觀察組血清VEGF、Ang-2水平均高于對(duì)照組，S100β、NSE水平均低于對(duì)照組（P<0.05）。治療后，兩組MMSE評(píng)分、MoCA評(píng)分均高于治療前（P<0.05），且觀察組MMSE評(píng)分、MoCA評(píng)分高于對(duì)照組（P<0.05）。治療后，兩組收縮期峰血流速度（V_s）、平均血流速度（V_m）均高于治療前，PI均低于治療前（P<0.05）；且觀察組V_s、V_m高于對(duì)照組，PI低于對(duì)照組（P<0.05）。結(jié)論 丁苯酞軟膠囊能減緩或逆轉(zhuǎn)中重度腦白質(zhì)疏松，改善患者認(rèn)知功能、腦血流情況，調(diào)節(jié)血清VEGF、Ang-2、S100β、NSE水平，值得臨床應(yīng)用推廣。

Objective To analyze the effects of Butylphthalide Soft Capsules on cognitive function, serum VEGF, Ang-2, S100β, NSE levels in patients with moderate and severe leukoencephalopathy. Methods A total of 98 patients with moderate to severe leukmatter osteoporosis admitted to Cangzhou Central Hospital from September 2019 to September 2020 were selected as the research subjects. According to the treatment methods, the patients were divided into control group and observation group, with 49 patients in each group. Patients in the control group were given routine treatment, including routine monitoring of blood pressure, blood glucose and other risk factors, and given symptomatic treatment. Patients in the observation group were additively treated with Butylphthalide Soft Capsules, 2 pills/time, 3 times daily. The two groups were treated for 12 weeks. The classification of Van Swieten scale, cognitive function, serum levels of VEGF, Ang-2, S100β, NSE, blood flow velocity of middle cerebral artery, and PI were compared between two groups.Results After treatment, the classification of Van Swieten scale in two groups was better than that before treatment (P < 0.05), and the classification of Van Swieten scale in the observation group was better than that in the control group (P < 0.05). After treatment, the levels of serum VEGF and Ang-2 were higher than before treatment, but the levels of S100β and NSE were lower than before treatment (P < 0.05). The levels of serum VEGF and Ang-2 in observation group were higher than those in control group, and the levels of S100β and NSE in observation group were lower than those in control group (P < 0.05). After treatment, MMSE and MOCA scores in two groups were higher than those before treatment (P < 0.05), and MMSE and MOCA scores in observation group were higher than those in control group (P < 0.05). After treatment, V_s and V_m in both groups were higher than before, and PI was lower than before (P < 0.05). V_s and V_m in observation group were higher than those in control group, and PI in observation group was lower than that in control group (P < 0.05). Conclusion Butylphthalide Soft Capsules can slow down or reverse moderate to severe cerebral white matter osteoporosis, improve cognitive function, cerebral blood flow, regulate serum VEGF, Ang-2, S100β, NSE levels, worthy of clinical application and promotion.

R971

滄州市重點(diǎn)研發(fā)計(jì)劃指導(dǎo)項(xiàng)目（172302020）