目的 觀察痹祺膠囊聯(lián)合甲氨蝶呤治療類風濕關(guān)節(jié)炎的臨床療效。方法 選取2018年5月—2020年12月邯鄲市中心醫(yī)院收治的200例類風濕關(guān)節(jié)炎患者，根據(jù)信封抽簽法將患者分為對照組和觀察組，每組各100例。對照組溫水送服甲氨蝶呤片，7.5 mg/次，1次/周。觀察組在對照組的基礎(chǔ)上溫水送服痹祺膠囊，4粒/次，3次/d。兩組連續(xù)治療12周。觀察兩組患者的臨床療效，同時比較兩組C反應(yīng)蛋白（CRP）、類風濕因子滴度（RF）、抗鏈球菌溶血素"O"（ASO）、紅細胞沉降率（ESR）、免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、免疫球蛋白M（IgM）及補體C3、C4水平。結(jié)果 治療后，觀察組的臨床總有效率為83.00%，顯著高于對照組的69.00%（P<0.05）。治療后，兩組CRP、ASO、ESR和RF水平均顯著下降（P<0.05）；治療后，觀察組的風濕四項指標水平顯著低于對照組（P<0.05）。治療后，兩組IgG、IgA、IgM均較治療前下降（P<0.05）；治療后，觀察組的IgA、IgM、IgG均低于對照組（P<0.05）。兩組治療前后補體C3、C4組間對比均未見統(tǒng)計學差異。結(jié)論 痹祺膠囊聯(lián)合甲氨蝶呤治療類風濕關(guān)節(jié)炎患者，可有效控制疾病進展，調(diào)節(jié)血清免疫球蛋白水平，提高治療效果。

Objective To observe the clinical efficacy of Biqi Capsules combined with methotrexate in treatment of rheumatoid arthritis.Methods A total of 200 patients with rheumatoid arthritis admitted to Handan Central Hospital from May 2018 to December 2020 were selected, and the patients were divided into control group and observation group according to the envelope lottery method, with 100 cases in each group. Patients in the control group were po administered with Methotrexate Tablets with warm water, 7.5 mg/time, once weekly. Patients in the observation group were po administered with Biqi Capsules on the basis of the control group, 4 capsules/time, 3 times daily. Both groups were treated for 12 weeks. The clinical efficacy of two groups was observed, and the levels of CRP, RF, ASO, ESR, IgA, IgG, IgM, complement C3 and C4 were compared between two groups. Results After treatment, the total clinical effective rate of observation group was 83.00%, which was significantly higher than 69.00% of control group (P < 0.05). After treatment, the levels of CRP, ASO, ESR and RF in two groups were significantly decreased (P < 0.05). After treatment, the four indexes of rheumatism in observation group were significantly lower than those in control group (P < 0.05). After treatment, IgG, IgA, and IgM in two groups were decreased compared with before treatment (P < 0.05). After treatment, IgA, IgM, and IgG in observation group were lower than those in control group (P < 0.05). There was no statistical difference in complement C3 and C4 between two groups before and after treatment.Conclusion Biqi Capsules combined with methotrexate in treatment of patients with rheumatoid arthritis can effectively control the disease progression, regulate the level of serum immunoglobulin, and improve the therapeutic effect.

R979.5

河北省醫(yī)學科學研究課題（20200477）