中藥-藥物的相互作用已成為藥物毒性研究的熱點(diǎn)。許多中藥的活性成分或其提取物在體內(nèi)的藥效和毒性與轉(zhuǎn)運(yùn)體相關(guān)，轉(zhuǎn)運(yùn)體的表達(dá)或活性可明顯影響中藥在體內(nèi)的藥動(dòng)學(xué)和生物活性。其中，基于轉(zhuǎn)運(yùn)體的馬兜鈴酸、雷公藤甲素等中藥成分的肝、腎毒性的研究十分廣泛，而中藥對(duì)轉(zhuǎn)運(yùn)體的作用也會(huì)對(duì)其他藥物的代謝產(chǎn)生影響從而發(fā)生藥物的相互作用。主要基于轉(zhuǎn)運(yùn)體角度來(lái)概述中藥毒性及對(duì)其他藥物代謝的影響，對(duì)中藥的毒性研究及臨床上的合理用藥具有指導(dǎo)意義。

Herbal-drug interacitons has become a hot sopt of drug toxicity researches. The potency and toxicity of many active ingredients or extracts of traditional Chinese medicines (TCMs) in vivo are related to transporters, and the expression of activity of the transporter could significantly affect the pharmacokinetics and biological activity of TCMs in the body. Among them, studies on the hepatorenal toxicity of aristolochic acid, triptolide and other TCMs ingredients based on transporters have been extensive. The effect of TCMs on transporters will also affect the metabolism of other drugs, resulting in drug interactions. This article summarized the toxicities of TCMs and the effects on metabolism of other drugs from the perspective of transporters, which has guiding significance for toxicity study of TCMs and rational drug use in clinical practice.

國(guó)家自然科學(xué)基金資助項(xiàng)目（81503347，81503068）；國(guó)家十三五“重大新藥創(chuàng)制”專項(xiàng)（2018ZX09201017）