何首烏Polygonum multiforum Thunb.是常用滋補(bǔ)中藥，廣泛應(yīng)用于臨床和保健產(chǎn)品，但是近年來不時(shí)出現(xiàn)何首烏及其制品致肝損傷的報(bào)道，引起關(guān)注。通過整理分析關(guān)于生首烏和制首烏的國內(nèi)外相關(guān)報(bào)道，從生首烏和制首烏致肝毒性的物質(zhì)基礎(chǔ)（水提物、醇提物、二苯乙烯苷、蒽醌類化合物和沒食子酸等）歸納總結(jié)其致肝毒性的藥理作用研究進(jìn)展。發(fā)現(xiàn)生首烏和制首烏的混淆以及長(zhǎng)期高劑量給藥可能是致肝損傷的主要原因。在不同病理動(dòng)物和細(xì)胞模型中總結(jié)分析何首烏化學(xué)成分，發(fā)現(xiàn)其化學(xué)成分的結(jié)構(gòu)以及成分之間的相互作用也是致肝損傷的原因之一。此外，何首烏引起的肝損傷是特征性的肝損傷，個(gè)體的體質(zhì)差異也是重要原因。

Radix Polygoni Multiflori (RPM) is widely used in clinical and health care products. In recent years, liver injury caused by RPM and its processed products have been reported, which has attracted and made substantial progress. The relevant reports about RPM and Radix Polygoni Multiflori Praeparata (RPMP) was collateed and analyzed, and the pharmacological research progress of hepatotoxicity caused by RPM and RPMP were summarized from the material basis of hepatotoxicity (such as water extract, alcohol extract, stilbene glycoside, anthraquinone and gallic acid). It was found that the confusion of RPM and RPMP and long-term high dose administration may be the main causes of liver injury. The chemical constituents of RPM were summarized and analyzed in different pathological animals and cell models. It was found that the structure and interaction of chemical components of RPM was also one of the causes of liver injury. In addition, the liver injury caused by RPM is a characteristic liver injury, and individual factors are also important causes.

R285.5

陜西中醫(yī)藥大學(xué)創(chuàng)新團(tuán)隊(duì)計(jì)劃（2019-QN02）；陜西中醫(yī)藥大學(xué)中藥藥性理論研究創(chuàng)新團(tuán)隊(duì)資助項(xiàng)目（2020XKTD-A04）