氧化苦參堿可防治高糖、高脂引起的心血管并發(fā)癥，脂肪肝并發(fā)癥，糖尿病視網(wǎng)膜病變，糖尿病腎病以及肺、骨并發(fā)癥。氧化苦參堿防治這些并發(fā)癥的藥理機制可能歸因于：降血糖、調(diào)血脂及抗氧化作用，從源頭上減少了氧化型低密度脂蛋白和糖基化終末產(chǎn)物的生成；抗氧化、抗炎和細胞保護作用可保護肝臟，促進肝糖原合成，在脂質(zhì)轉(zhuǎn)運、氧化和合成3個環(huán)節(jié)改善脂質(zhì)代謝紊亂，產(chǎn)生降血糖、調(diào)血脂作用，也可保護受累的心血管系統(tǒng)、腎臟、肝臟、視網(wǎng)膜、肺和骨等其他器官，減輕胰島素抵抗，提高胰島素敏感性。因此氧化苦參堿有望開發(fā)為治療代謝綜合征的藥物。

Oxymatrine prevents and treats for cardiovascular complication, fatty liver complication, diabetic retinopathy, diabetic renopathy, and the complications of lung and bone induced by hyperglycystia and hyperliposis. The mechanisms to prevent and treat for the complications are:the effects on hypoglycemia, hypolipemia and antioxidation of oxymatrine decrease the products of AGEs and ox-LDL from source; the effects on antioxidation, anti-inflammation and cellular protection of oxymatrine protect liver, improve glycogen synthesis, and lipid metabolism disturbance in lipid transport, oxidation and synthesis, and product the effects of hypoglycemia and hypolipemia, protect suffering organs of cardiovascullar system, ren, liver, retina, lung and bone, alleviate insulin resistance, and increase insulin sensitivity. So oxymatrine is hopeful to become a drug of treating metabolic syndrome.

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