注射用益氣復(fù)脈（凍干）（YQFM）在心血管系統(tǒng)的藥理研究主要包括抗心衰、改善心肌缺血、改善心肌肥厚以及缺血缺氧造成的心肌損傷。近年來，大量研究表明YQFM通過增強(qiáng)心肌收縮力、延緩心室重構(gòu)對(duì)缺血缺氧造成的心肌損傷有很好的保護(hù)作用；其藥理機(jī)制主要有抗炎、抗氧化、改善能量代謝及保護(hù)心功能，并且通過調(diào)節(jié)細(xì)胞自噬、抑制心肌細(xì)胞凋亡等對(duì)受損心肌進(jìn)行保護(hù)。

The modern pharmacological research of Yiqi Fumai Lyophilized Injection (YQFM) is mainly on the effects of cardiovascular system, including heart failure, myocardial ischemia and hypoxia injury. In recent years, a large number of studies have been carried out on the efficacy and mechanism of YQFM, and the results showed that YQFM can enhance the myocardial contractility of heart failure, delay ventricular remodeling and have a perfect protective effect on myocardial injury caused by ischemia and hypoxia. In addition, the involved mechanisms include anti-inflammation, anti-oxidation, improvement of energy metabolism and cardiac function, inhibition of myocardial apoptosis by regulating autophagy.

R285.5

天津理工大學(xué)2020年大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃項(xiàng)目（202010060091）