丹參Salvia miltiorrhiza因具有活血化瘀的功效在臨床上被廣泛使用，以其有效成分制成的丹參類制劑的應(yīng)用范圍也不斷擴(kuò)大。近年來(lái)圍繞注射用丹參多酚酸、注射用丹參多酚酸鹽、丹紅注射液、丹參注射液等丹參類制劑及其單體成分（如丹酚酸A、丹酚酸B、丹參素、迷迭香酸等）在治療心腦血管系統(tǒng)方面開(kāi)展了大量藥理機(jī)制的研究，表明其可以通過(guò)調(diào)控核因子-κB（NF-κB）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）、絲裂原活化蛋白激酶（MAPK）、Janus酪氨酸蛋白激酶（JAK）/信號(hào)轉(zhuǎn)導(dǎo)及轉(zhuǎn)錄激活因子（STAT）等多種信號(hào)通路，發(fā)揮抗炎、抗氧化、抑制凋亡等藥理作用。歸納總結(jié)丹參中的單體化合物及丹參類制劑對(duì)心腦血管系統(tǒng)相關(guān)信號(hào)通路的藥理作用，以期為注射用丹參多酚酸藥理作用分子機(jī)制的研究提供依據(jù)。

Salvia miltiorrhiza is widely used in clinic because of its effect of promoting blood circulation and removing blood stasis. The application range of modern Salvia miltiorrhiza preparations made from its active ingredients is also expanding. In recent years, a large number of pharmacological mechanisms have been studied on Salvianolic Acid for Injection, Salvianolate for Injection, Danhong Injection, Danshen Injection and other salvianolic acid preparations, as well as their monomeric components, such as salvianolic acid A, salvianolic acid B, danshensu and rosinic acid in the treatment of cardiovascular and cerebrovascular systems., and it has been shown that it has passed the preliminary exploration of nuclear factor-κB (NF-κB) and phosphatidylinositol 3 -Kinase (PI3K)/protein kinase B (Akt), mitogen-activated protein kinase (MAPK), Janus tyrosine protein kinase(JAK)/signal transducer and activator of transcription (STAT) and other signaling pathway anti-inflammatory, anti-oxidant, inhibit apoptosis and other effects. This study summarized the relevant signal pathways by consulting relevant literature, hoping to provide ideas for future research on the molecular mechanism of Salvianolic Acid for Injection.

R285.5