目的 觀察注射用益氣復(fù)脈（凍干）對(duì)不穩(wěn)定型心絞痛（氣陰兩虛證）患者低密度脂蛋白膽固醇（LDL-C）的影響及中醫(yī)癥候的療效。方法 回顧性選取2020年6月—2021年6月淮北市中醫(yī)院心內(nèi)科住院的不穩(wěn)定型心絞痛患者102例為研究對(duì)象，根據(jù)治療方法將患者分為對(duì)照組（n=51）和觀察組（n=51）。對(duì)照組患者給予阿托伐他汀鈣片、阿司匹林腸溶片、硫酸氫氯吡格雷片、單硝酸異山梨酯緩釋片等藥物治療，觀察組患者在對(duì)照組基礎(chǔ)上聯(lián)合注射用益氣復(fù)脈（凍干）5.2 g溶于0.9%氯化鈉注射液200 mL中，靜脈滴注，1次/d。兩組治療療程均為2周。比較治療前及治療1周末、治療2周末兩組患者的心絞痛發(fā)作次數(shù)、中醫(yī)癥候積分、LDL-C等指標(biāo)。結(jié)果 與治療前比較，兩組治療1周末、治療2周末患者心絞痛發(fā)作次數(shù)、中醫(yī)癥候積分均顯著降低（P<0.05、0.01），與治療1周末比較，觀察組治療2周末心絞痛發(fā)作次數(shù)、中醫(yī)癥候積分、LDL-C降低更明顯（P<0.05）。與對(duì)照組同時(shí)間比較，觀察組治療1周末、治療2周末的心絞痛發(fā)作次數(shù)、中醫(yī)癥候積分顯著降低（P<0.05）；中醫(yī)癥候療效觀察組總有效率（86.3%）高于對(duì)照組（68.6%，P<0.05）；觀察組的心絞痛改善情況總有效率（88.2%）優(yōu)于對(duì)照組（70.6%，P<0.05）。結(jié)論 注射用益氣復(fù)脈（凍干）能進(jìn)一步改善不穩(wěn)定型心絞痛（氣陰兩虛證）患者的LDL-C水平及中醫(yī)癥候積分，減少心絞痛發(fā)作，且安全、有效。

Objective To observe the effect of Yiqi Fumai Lyophilized Injection on low density lipoprotein cholesterol in patients with unstable angina pectoris (qi yin deficiency syndrome) and the curative effect on traditional Chinese medicine symptoms. Methods Total 102 patients with unstable angina pectoris hospitalized in the Department of Cardiology of Huaibei Hospital of traditional Chinese Medicine from June 2020 to June 2021 were selected retrospectively. According to the treatment methods, the patients were divided into control group (n=51) and observation group (n=51). The patients in the control group were treated with Atorvastatin Calcium Tablets, Aspirin Enteric Coated Tablets, Clopidogrel Bisulfate Tablets, Isosorbide Mononitrate for Injection, Isosorbide Mononitrate Sustained Release Tablets and other drugs. On the basis of the control group, the patients in the observation group were combined with 5.2 g of Yiqi Fumai Lyophilized Injection, dissolved in 200 mL of 0.9% sodium chloride injection, intravenous drip, once a day. The treatment course of both groups were two weeks. The frequency of angina pectoris attack, TCM symptom score, low density lipoprotein cholesterol (LDL-C) and other indexes were compared between two groups before treatment, at the end of the first week and at the end of the second weeks. Results Compared with before treatment, the number of angina pectoris attacks and TCM symptom score in two groups at the end of the first week and the second week of treatment were significantly lower (P<0.05, 0.01). Compared with the first week of treatment, the number of angina pectoris attacks, TCM symptom score and LDL-C in the observation group at the end of the second week of treatment were significantly lower (P<0.05). Compared with the control group at the same time, the number of angina pectoris attacks and TCM syndrome score in the observation group at the end of the first week and the second weeks after treatment were significantly reduced (P<0.05). The total effective rate of TCM syndrome effect observation group (86.3%) was higher than that in the control group (68.6%, P<0.05). The total effective rate of angina pectoris improvement observation group (88.2%) was better than that in the control group (70.6%, P<0.05). Conclusion Yiqi Fumai Lyophilized Injection can further improve the LDL-C level and TCM syndrome score of patients with unstable angina pectoris (qi yin deficiency syndrome), reduce the attack of angina pectoris, and is safe and effective.

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