目的 探討阿司匹林聯(lián)合硫酸鎂治療妊娠高血壓綜合征（HDP）的臨床療效。方法 選取2019年1月—2020年11月于臨沂市人民醫(yī)院產(chǎn)科確診并治療的114例HDP患者作為研究對(duì)象，根據(jù)治療方法的不同，將患者分為對(duì)照組和試驗(yàn)組，每組各57例。對(duì)照組靜脈滴注硫酸鎂注射液，20 g與1 000 mL的葡萄糖注射液充分混合，滴速：1～1.5 g/h；1次/d。試驗(yàn)組在對(duì)照組的基礎(chǔ)上口服阿司匹林腸溶片，100 mg/次，1次/d。4周為1個(gè)療程，兩組連續(xù)治療2個(gè)療程。觀察兩組患者的臨床療效和順產(chǎn)率，同時(shí)比較兩組治療前后的平均動(dòng)脈壓（MAP）水平、凝血酶原時(shí)間（PT）、部分活化凝血酶原時(shí)間（APTT）、凝血酶時(shí)間（TT）和纖維蛋白原（FIB）水平。結(jié)果 治療后，試驗(yàn)組總有效率為96.5%，顯著高于對(duì)照組的 78.9%（P<0.05）。治療后，兩組各時(shí)間點(diǎn)MAP水平均顯著降低（P<0.05）；且試驗(yàn)組的MAP水平顯著低于同期對(duì)照組（P<0.05）。治療后，兩組PT、APTT及TT均顯著延長，F(xiàn)IB水平顯著降低（P<0.05）；試驗(yàn)組凝血功能指標(biāo)顯著優(yōu)于對(duì)照組（P<0.05）。治療后，試驗(yàn)組順產(chǎn)率顯著高于對(duì)照組（P<0.05）。結(jié)論 阿司匹林聯(lián)合硫酸鎂治療HDP可顯著降低 MAP和FIB水平，延長APTT、TT及PT，提高HDP患者的順產(chǎn)率。

Objective To investigate the clinical efficacy of aspirin combined with magnesium sulfate in the treatment of hypertensive syndrome of pregnancy (HDP). Methods A total of 114 HDP patients diagnosed and treated from January 2019 to November 2020 were selected as the study subjects. According to different treatment methods, the patients were divided into control group and experimental group, with 57 cases in each group. Patients in the control group were iv administered with Magnesium Sulfate Injection, 20 g added into 1 000 mL glucose injection, the drip rate was 1 — 1.5 g/h, once daily. Patients in the experimental group were po administered with Aspirin Enteric-coated Tablets 100 mg/time, once daily on the basis of control group. Four weeks was a course of treatment, and the two groups were treated for two courses. Clinical efficacy and birth rate of two groups were observed, and the mean arterial pressure (MAP), prothrombin time (PT), APTT, TT, and FIB levels before and after treatment were compared between two groups. Results After treatment, the total effective rate of observation group was 96.5%, which was significantly higher than 78.9% of control group (P<0.05). After treatment, MAP level at each time node in two groups was significantly decreased (P<0.05). The MAP level in the experimental group was significantly lower than that in the control group (P<0.05). After treatment, PT, APTT and TT in two groups were significantly prolonged, FIB level was significantly decreased (P<0.05). The coagulation function index of the experimental group was significantly better than that of the control group (P<0.05). After treatment, the birth rate of experimental group was significantly higher than that of control group (P<0.05). Conclusion Aspirin combined with magnesium sulfate in treatment of HDP can significantly reduce MAP and FIB levels, prolong APTT, TT and PT, and improve the vaginal delivery rate of HDP patients.

R984

臨沂市科技發(fā)展計(jì)劃項(xiàng)目（201213020）