左金方為元朝醫(yī)家朱震亨創(chuàng)制的經(jīng)典中藥復(fù)方，始載于《丹溪心法》，僅由黃連、吳茱萸以6∶1比例組方，治療肝火犯胃所致脅肋脹痛、吞酸嘔吐等，如今不僅用于多種消化系統(tǒng)病癥（如胃潰瘍、胃炎、胃癌、幽門螺桿菌感染等），還在精神癥狀、非胃腸道腫瘤、高血壓、糖尿病等非消化系統(tǒng)疾病的治療中起到較好療效，具有抗炎抗?jié)?、抗腫瘤、抗菌等多種作用。就近5年來(lái)對(duì)左金方的化學(xué)成分與藥理作用的研究進(jìn)展進(jìn)行歸納總結(jié)，同時(shí)對(duì)其未來(lái)可能的研究方向進(jìn)行了展望，以期為其進(jìn)一步綜合開發(fā)利用奠定基礎(chǔ)。

Zuojin Formula (ZJF), a classical herbal compound, is created by Zhu Zhenheng, a physician in Yuan Dynasty. First published in his classic "Dan Xi Xin Fa", it was only made from Rhizoma coptis and Evodia rutaecarpa respectively in a ratio of 6∶ 1, and the traditional dosage forms of it were water-bindered pill and decoction. Though it was originally used for the treatment of flank pain, gastric acid regurgitation and vomiting caused by liver-fire offending the stomach. Nowadays it can not only be used for a variety of digestive disorders, such as gastric ulcer, gastritis, gastric carcinoma and H. pylori infection, but also plays a pivotal role in the treatment of mental disorders, non-gastrointestinal tumor, hypertension, diabetes and other non-digestive diseases, showing multiple effects such as anti-inflammation, anti-ulcer, anti-tumor and anti-bacteria. This article comprehensively summarizes the research progress in respect of chemical compositions and pharmacological effects of ZJF in the past five years. At the same time prospects the possible research directions in the future, hoping to provide a reference for the further research.

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深圳市知識(shí)創(chuàng)新基礎(chǔ)研究（JCYJ20170818094033689）；深圳市戰(zhàn)略新興產(chǎn)業(yè)發(fā)展專項(xiàng)資金（JCYJ20130326112248968）；深圳大學(xué)聚徒＋創(chuàng)研項(xiàng)目（2021年度）