厚樸系木蘭科植物厚樸Magnolia officinalis或凹葉厚樸M.officinalis var.biloba的干燥干皮、根皮及枝皮，具有燥濕消痰、下氣除滿的功效。厚樸提取物、厚樸酚及和厚樸酚是厚樸抗炎的主要活性成分，其抗炎機(jī)制有：阻滯磷脂酰肌醇-3激酶/蛋白激酶B（PI3K/Akt）、細(xì)胞外調(diào)節(jié)蛋白激酶/絲裂原活化蛋白激酶（ERK/MAPK）和把關(guān)受體-2/絲裂原活化蛋白激酶（TLR/MAPK）信號(hào)通路，抑制炎性細(xì)胞因子表達(dá)；還可通過(guò)直接抑制誘導(dǎo)型一氧化氮合酶（iNOS）、環(huán)氧化酶-2（COX-2）、5-脂氧化酶（5-LO）的酶活性，阻滯炎癥介質(zhì)一氧化氮、前列腺素（PGs）、白三烯（LTs）的合成和釋放，以及抑制組織胺釋放等，產(chǎn)生廣譜的抗炎作用。厚樸提取物、厚樸酚及和厚樸酚的抗氧化活性也是其抗炎作用的主要機(jī)制之一。厚樸為常用的非毒性中藥，可以把研究重點(diǎn)放在防治慢性的或退行性疾病的微炎癥方面。

Magnolol Offcinalia Cortex is dry cortex of trunk, root and branch from Magnolia officinalis Rehd. et Wils. or M. officinalis Rehd. et Wils. var. biloba Rehd. et Wils., and have the efficiency of drying dampness to eliminate phlegm, and descending qi to expel fullness. Magnolol and honokiol are principal active compositions against inflammation in Magnoliae Officinalis Cortex. Their mechanisms are: blocking these signaling pathways of PI3K/Akt, ERK/MAPK and TLR/MAPK, to inhibit the expression of inflammatory cytokines; and blocking biosynthesis and release of inflammatory mediators nitric oxide, prostaglandins and leukotrienes by direct inhibition enzymic activity of iNOS, COX-2 and 5-LO; and blocking histamine release; so to produce braodspectrum anti-inflammation. Antioxidation of Mgnoliae Officinalis Cortex, magnolol and honokiol are among the major mechanisms in anti-inflammation too. Magnolol Offcinalia Cortex is a medicinal herb most in use and low toxic, researching focal point should be to prevent and treat for microinflammation in chronic or degenerate diseases.

R285.5