目的 探討蒙藥扎沖十三味丸對腦缺血大鼠神經(jīng)功能的影響。方法 SD大鼠隨機(jī)分為假手術(shù)組、模型組、尼莫地平（陽性對照，0.02 g·kg^-1）組和扎沖十三味丸高、中、低劑量（0.24、0.12、0.06 g·kg^-1）組，除假手術(shù)組外，其余組大鼠采用ip硝普鈉2 mL·kg^-1合并雙側(cè)頸總動脈結(jié)扎制備腦缺血模型，于術(shù)前2 h給藥1次，術(shù)后連續(xù)給藥5 d。術(shù)后24、72、120 h進(jìn)行神經(jīng)病學(xué)癥狀評分、平衡木行走實(shí)驗(yàn)、肌力評定實(shí)驗(yàn)和曠場實(shí)驗(yàn)。結(jié)果 與模型組比較，在術(shù)后24 h，扎沖十三味丸高、中劑量組和尼莫地平組神經(jīng)病學(xué)癥狀評分顯著降低（P<0.05）；在術(shù)后72、120 h，扎沖十三味丸高、中、低劑量組和尼莫地平組神經(jīng)病學(xué)癥狀評分均顯著降低（P<0.05）。與模型組比較，扎沖十三味丸高、中劑量組和尼莫地平組在術(shù)后72和120 h平衡木行走評分均顯著降低（P<0.05）。與模型組比較，術(shù)后72、120 h，扎沖十三味丸高劑量組大鼠肌力評分顯著升高（P<0.05）。與模型組比較，扎沖十三味丸高、中、低劑量組和尼莫地平組各時(shí)相大鼠跨格次數(shù)顯著減少（P<0.05）；扎沖十三味丸高劑量組和尼莫地平組各時(shí)相大鼠站立次數(shù)顯著減少（P<0.05），扎沖十三味丸中劑量術(shù)后24、120 h以及低劑量組術(shù)后120 h大鼠站立次數(shù)均顯著減少（P<0.05）。結(jié)論 扎沖十三味丸可改善腦缺血神經(jīng)功能障礙，改善受損大鼠運(yùn)動失調(diào)、偏癱和焦慮情緒。

Objective To investigate the effect of Mongolian medicine Zhachong 13 Pill on neural function in rats with cerebral ischemia. Methods SD rats were randomly divided into sham operation group, model group, Zhachong 13 Pill high, medium and low-dose (0.24, 0.12 and 0.06 g·kg^-1) group and nimodipine (positive control, 0.02 g·kg^-1) group. The other groups were treated with ip sodium nitroprusside 2 mL·kg^-1 combined with bilateral common carotid artery ligation to prepare cerebral ischemia model. The rats were administered once 2 h before surgery and continuously for 5 d after surgery. Neurological symptom score, balance beam walking test, muscle strength assessment test and open field test were performed at 24, 72 and 120 h postoperatively. Results Compared with model group, 24 h after surgery, neurological score of Zhachong 13 Pill high and medium dose groups and nimodipine group was significantly decreased (P < 0.05). At 72 and 120 h postoperatively, neurological scores in Zhachong 13 Pill high, medium and low-dose groups and nimodipine group were significantly decreased (P < 0.05). Compared with model group, balance beam walking score in Zhachong 13 Pill high and medium dose groups and nimodipine group was significantly decreased at 72 and 120 h after surgery (P < 0.05). Compared with model group, muscle strength score of Zhachong 13 Pill high group was significantly increased at 72 and 120 h after surgery (P < 0.05). Compared with model group, the number of translatations in Zhachong 13 Pill high, medium and low dose groups and nimodipine groups were significantly decreased (P < 0.05). The standing times of Zhachong 13 Pill high dose group and nimodipine group were significantly decreased at each time phase (P < 0.05), and the standing times of Zhachong 13 Pill medium dose group and low dose group were significantly decreased at 24, 120 h after surgery (P < 0.05). Conclusion Zhachong 13 Pill can improve the neurological dysfunction of cerebral ischemia, dyskinesia, hemiplegia and anxiety in rats.

R285.5

內(nèi)蒙古自治區(qū)高等學(xué)校科學(xué)研究項(xiàng)目（NJZY20177）；內(nèi)蒙古自治區(qū)高等學(xué)?？茖W(xué)研究項(xiàng)目（NJZY21054）；自治區(qū)級大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃項(xiàng)目（201910127010）