厚樸系木蘭科植物厚樸Magnolia officinalis或凹葉厚樸M.officinalis Rehd.et Wils.var.biloba的干燥干皮、根皮及枝皮，具有燥濕消痰、下氣除滿的功效。厚樸提取物、厚樸酚及和厚樸酚都具有抗炎、抗氧化和抗衰老作用，厚樸酚及和厚樸酚是厚樸抗炎、抗氧化和抗衰老的主要活性成分。它們的抗氧化能力是通過(guò)對(duì)自由基的直接清除作用以及提高機(jī)體的抗氧化酶活性間接猝滅自由基表現(xiàn)出來(lái)。因此厚樸提取物、厚樸酚及和厚樸酚能防治各種氧化應(yīng)激性炎性疾病，長(zhǎng)期應(yīng)用可能有防治機(jī)體衰老發(fā)生發(fā)展的作用。綜述厚樸提取物、厚樸酚及和厚樸酚的抗氧化和抗衰老藥理作用研究進(jìn)展，以期為抗氧化和抗衰老的新藥研發(fā)提供依據(jù)。

Magnoliae Officinalis Cortex is dry cortex of trunk, root and branch from Magnolia officinalis or M. officinalis Rehd. et Wils. var. biloba, and have the efficiency of drying dampness to eliminate phlegm, and descending qi to expel fullness. Magnolol and honokiol are extract from Magnoliae Officinalis Cortex, they all have the effects of anti-inflammation, antioxidation and antiaging. Magnolol and honokiol are principal active compositions against inflammation, oxidation and aging in Magnoliae Officinalis Cortex. Their antioxidations are showed by scavenging direct free radical, and eliminating indirect free radical through increasing activity of antioxidases, so extract, magnolol and honokiol from Magnoliae Officinalis Cortex prevent and treat various inflammatory diseases induced by oxidative stress, and their usage with long-term maybe have the actions of preventing and treating for aging. The present paper presents overview of pharmacologic antioxidation and anti-aging of extract, magnolol and honokiol from Magnoliae Officinalis Cortex in order to provides references for the new drug development of antioxidation and antiinflammation.

R287.5