多數(shù)生物體內存在固有的生物節(jié)律，它調節(jié)機體生命活動過程以適應外界環(huán)境的變化。晝夜節(jié)律由中央生物鐘及外周生物鐘共同協(xié)調控制。動脈粥樣硬化性心血管疾病（ACVD）目前仍是世界范圍內的第一大致死性因素。研究表明，ACVD的發(fā)病特點與生物鐘之間具有高度相關性。主要介紹生物鐘調節(jié)脂質代謝及免疫炎癥反應的生物學作用，及其對局部血管功能的影響，探討以生物鐘為潛在靶點的藥物研究現(xiàn)狀及其對臨床精準用藥的指導，以期將生物鐘療法廣泛應用于ACVD的治療中。

Most organisms have internal biological rhythm, which regulate biological processes in response to changes in the daily environment. Circadian rhythms are coordinated by central clock and peripheral clock. Atherosclerosis cardiovascular disease (ACVD) is the main cause of death all over the world. Recent studies have shown that there is a strong correlation between the circadian clock and ACVD. In this review, we briefly summarize the key roles of circadian clock in ACVD, including regulation of lipid metabolism, inflammatory immunoreactions, vascular functions. And we also discuss the status quo of drug research based on circadian clock and its guidance on clinical precision medication, in order to apply the chronotherapy in the treatment of ACVD widely.

R972

山東省高等學?？萍加媱濏椖?J18KB117)