生殖發(fā)育毒性評價是藥物安全性評價的重要組成部分。家兔屬兔科兔形目，是藥物生殖發(fā)育毒性評價的非嚙齒類哺乳動物模型之一，但是其相關(guān)研究較嚙齒動物少，對不同種屬動物模型進行藥物生殖發(fā)育毒性評價有助于提高風險評估的準確性。從生育力與早期胚胎發(fā)育毒性試驗、胚胎-胎仔發(fā)育毒性試驗、圍產(chǎn)期發(fā)育毒性試驗和體外生殖發(fā)育毒性評價等方面綜述了家兔在藥物生殖發(fā)育毒性評價中的研究進展，并探討了家兔在藥物生殖發(fā)育毒性評價研究中存在的問題及今后的發(fā)展方向，以期為今后研究提供參考。

Developmental and reproductive toxicity evaluation is an important part of drug safety evaluation. Rabbit, a member of the Lagomorpha order, are one of the non-rodent animal models for drug developmental and reproductive toxicity evaluation. However, there are fewer related studies than rodents, and the evaluation of drug developmental and reproductive toxicity in different species animal models can help improve the accuracy of risk assessment. This paper mainly review the the research progress of drug developmental and reproductive toxicity evaluation in rabbit, including fertility and early embryonic development toxicity study, embryo-fetal developmental toxicity study, pre-postnatal and postnatal development toxicity study and in vitro developmental and reproductive toxicity evaluation, and also discuss the problems and future development directions in the evaluation of drug reproductive and developmental toxicity in rabbit, hoping to provide references for the follow-up research.

R965.3

中國食品藥品檢定研究院中青年發(fā)展研究基金課題(2020C1)